Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression
Lard diet (LD) is a risk factor for prostate cancer (PCa) development and progression. Two immunocompetent mouse models fed with isocaloric specific fat diets (LD) enriched in saturated and monounsaturated fatty acid (SMFA), showed significanftly enhanced PCa progression with weight gain compared wi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/4/2214 |
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| author | Hiromi Sato Shintaro Narita Masanori Ishida Yoshiko Takahashi Huang Mingguo Soki Kashima Ryohei Yamamoto Atsushi Koizumi Taketoshi Nara Kazuyuki Numakura Mitsuru Saito Toshiaki Yoshioka Tomonori Habuchi |
| author_facet | Hiromi Sato Shintaro Narita Masanori Ishida Yoshiko Takahashi Huang Mingguo Soki Kashima Ryohei Yamamoto Atsushi Koizumi Taketoshi Nara Kazuyuki Numakura Mitsuru Saito Toshiaki Yoshioka Tomonori Habuchi |
| author_sort | Hiromi Sato |
| collection | DOAJ |
| description | Lard diet (LD) is a risk factor for prostate cancer (PCa) development and progression. Two immunocompetent mouse models fed with isocaloric specific fat diets (LD) enriched in saturated and monounsaturated fatty acid (SMFA), showed significanftly enhanced PCa progression with weight gain compared with a fish oil diet (FOD). High gut microbial divergency resulted from difference in diets, and the abundance of several bacterial species, such as in the orders Clostridiales and Lactobacillales, was markedly altered in the feces of LD- or FOD-fed mice. The proportion of the order Lactobacillales in the gut was negatively involved in SMFA-induced body weight gain and PCa progression. We found the modulation of lipid metabolism and cholesterol biosynthesis pathways with three and seven commonly up- and downregulated genes in PCa tissues, and some of them correlated with the abundance of the order Lactobacillales in mouse gut. The expression of sphingosine 1-phosphate receptor 2, which is associated with the order Lactobacillales and cancer progression in mouse models, was inversely associated with aggressive phenotype and weight gain in patients with PCa using the NCBI Gene Expression Omnibus database. Therefore, SMFA may promote PCa progression with the abundance of specific gut microbial species and overexpression of lipogenic genes in PCa. Therapeutics with alteration of gut microbiota and candidate genes involved in diet-induced PCa progression may be attractive in PCa. |
| first_indexed | 2024-03-09T21:43:58Z |
| format | Article |
| id | doaj.art-4faf99f95322423e8992acb36b93a0fd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:43:58Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4faf99f95322423e8992acb36b93a0fd2023-11-23T20:21:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01234221410.3390/ijms23042214Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and ProgressionHiromi Sato0Shintaro Narita1Masanori Ishida2Yoshiko Takahashi3Huang Mingguo4Soki Kashima5Ryohei Yamamoto6Atsushi Koizumi7Taketoshi Nara8Kazuyuki Numakura9Mitsuru Saito10Toshiaki Yoshioka11Tomonori Habuchi12Department of Urology, Akita University School of Medicine, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanField of Basic Science, Department of Occupational Therapy, Akita University Graduate School of Health Science, Akita 010-8543, JapanDepartment of Urology, Akita University School of Medicine, Akita 010-8543, JapanLard diet (LD) is a risk factor for prostate cancer (PCa) development and progression. Two immunocompetent mouse models fed with isocaloric specific fat diets (LD) enriched in saturated and monounsaturated fatty acid (SMFA), showed significanftly enhanced PCa progression with weight gain compared with a fish oil diet (FOD). High gut microbial divergency resulted from difference in diets, and the abundance of several bacterial species, such as in the orders Clostridiales and Lactobacillales, was markedly altered in the feces of LD- or FOD-fed mice. The proportion of the order Lactobacillales in the gut was negatively involved in SMFA-induced body weight gain and PCa progression. We found the modulation of lipid metabolism and cholesterol biosynthesis pathways with three and seven commonly up- and downregulated genes in PCa tissues, and some of them correlated with the abundance of the order Lactobacillales in mouse gut. The expression of sphingosine 1-phosphate receptor 2, which is associated with the order Lactobacillales and cancer progression in mouse models, was inversely associated with aggressive phenotype and weight gain in patients with PCa using the NCBI Gene Expression Omnibus database. Therefore, SMFA may promote PCa progression with the abundance of specific gut microbial species and overexpression of lipogenic genes in PCa. Therapeutics with alteration of gut microbiota and candidate genes involved in diet-induced PCa progression may be attractive in PCa.https://www.mdpi.com/1422-0067/23/4/2214prostate cancersaturated fatty acidmonounsaturated fatty acidgut microbiotalipid metabolism |
| spellingShingle | Hiromi Sato Shintaro Narita Masanori Ishida Yoshiko Takahashi Huang Mingguo Soki Kashima Ryohei Yamamoto Atsushi Koizumi Taketoshi Nara Kazuyuki Numakura Mitsuru Saito Toshiaki Yoshioka Tomonori Habuchi Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression International Journal of Molecular Sciences prostate cancer saturated fatty acid monounsaturated fatty acid gut microbiota lipid metabolism |
| title | Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression |
| title_full | Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression |
| title_fullStr | Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression |
| title_full_unstemmed | Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression |
| title_short | Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression |
| title_sort | specific gut microbial environment in lard diet induced prostate cancer development and progression |
| topic | prostate cancer saturated fatty acid monounsaturated fatty acid gut microbiota lipid metabolism |
| url | https://www.mdpi.com/1422-0067/23/4/2214 |
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