Constituents of <i>Huberantha jenkinsii</i> and Their Biological Activities

The phytochemical investigation of <i>Huberantha jenkinsii</i> resulted in the isolation of two new and five known compounds. The new compounds were characterized as undescribed 8-oxoprotoberberine alkaloids and named huberanthines A and B, whereas the known compounds were identified as...

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Main Authors: Htoo Tint San, Tanawat Chaowasku, Wanwimon Mekboonsonglarp, Ratchanee Rodsiri, Boonchoo Sritularak, Hathairat Buraphaka, Waraporn Putalun, Kittisak Likhitwitayawuid
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/25/15/3533
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Summary:The phytochemical investigation of <i>Huberantha jenkinsii</i> resulted in the isolation of two new and five known compounds. The new compounds were characterized as undescribed 8-oxoprotoberberine alkaloids and named huberanthines A and B, whereas the known compounds were identified as allantoin, oxylopinine, <i>N</i>-<i>trans</i>-feruloyl tyramine, <i>N-trans-p-</i>coumaroyl tyramine, and mangiferin. The structure determination was accomplished by spectroscopic methods. To evaluate therapeutic potential in diabetes and Parkinson’s disease, the isolates were subjected to assays for their α-glucosidase inhibitory activity, cellular glucose uptake stimulatory activity, and protective activity against neurotoxicity induced by 6-hydroxydopamine (6-OHDA). The results suggested that mangiferin was the most promising lead compound, demonstrating significant activity in all the test systems.
ISSN:1420-3049