Phenotypic, molecular, and in silico characterization of coumarin as carbapenemase inhibitor to fight carbapenem-resistant Klebsiella pneumoniae

Phenotypic, molecular, and in silico characterization of coumarin as carbapenemase inhibitor to fight carbapenem-resistant Klebsiella pneumoniae

Abstract Background Carbapenems represent the first line treatment of serious infections caused by drug-resistant Klebsiella pneumoniae. Carbapenem-resistant K. pneumoniae (CRKP) is one of the urgent threats to human health worldwide. The current study aims to evaluate the carbapenemase inhibitory p...

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Bibliographic Details
Main Authors: Mahmoud Saad Abdel-Halim, Amira M. El-Ganiny, Basem Mansour, Galal Yahya, Hemat K. Abd El Latif, Momen Askoura
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Microbiology
Subjects:
Klebsiella pneumoniae
Carbapenem-resistant
Coumarin
qRT-PCR
Checkerboard assay
Molecular docking
Online Access:https://doi.org/10.1186/s12866-024-03214-7

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