The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review
Fetal exposure in adverse environmental factors during intrauterine life can lead to various biological adjustments, affecting not only in utero development of the conceptus, but also its later metabolic and endocrine wellbeing. During human gestation, maternal bone turnover increases, as reflected...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/15/8328 |
| _version_ | 1797441959693910016 |
|---|---|
| author | Angelos Dimas Anastasia Politi Alexandra Bargiota Theodoros Panoskaltsis Nikolaos F. Vlahos Georgios Valsamakis |
| author_facet | Angelos Dimas Anastasia Politi Alexandra Bargiota Theodoros Panoskaltsis Nikolaos F. Vlahos Georgios Valsamakis |
| author_sort | Angelos Dimas |
| collection | DOAJ |
| description | Fetal exposure in adverse environmental factors during intrauterine life can lead to various biological adjustments, affecting not only in utero development of the conceptus, but also its later metabolic and endocrine wellbeing. During human gestation, maternal bone turnover increases, as reflected by molecules involved in bone metabolism, such as vitamin D, osteocalcin, sclerostin, sRANKL, and osteoprotegerin; however, recent studies support their emerging role in endocrine functions and glucose homeostasis regulation. Herein, we sought to systematically review current knowledge on the effects of aforementioned maternal bone biomarkers during pregnancy on fetal intrauterine growth and metabolism, neonatal anthropometric measures at birth, as well as on future endocrine and metabolic wellbeing of the offspring. A growing body of literature converges on the view that maternal bone turnover is likely implicated in fetal growth, and at least to some extent, in neonatal and childhood body composition and metabolic wellbeing. Maternal sclerostin and sRANKL are positively linked with fetal abdominal circumference and subcutaneous fat deposition, contributing to greater birthweights. Vitamin D deficiency correlates with lower birthweights, while research is still needed on intrauterine fetal metabolism, as well as on vitamin D dosing supplementation during pregnancy, to diminish the risks of low birthweight or SGA neonates in high-risk populations. |
| first_indexed | 2024-03-09T12:34:51Z |
| format | Article |
| id | doaj.art-4fb162fcf7dc47519f3a887e0a4147a3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:34:51Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4fb162fcf7dc47519f3a887e0a4147a32023-11-30T22:25:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315832810.3390/ijms23158328The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic ReviewAngelos Dimas0Anastasia Politi1Alexandra Bargiota2Theodoros Panoskaltsis3Nikolaos F. Vlahos4Georgios Valsamakis53rd University Department of Obstetrics & Gynecology, Attikon University Hospital, Medical School of Athens, Ethnikon and Kapodistriakon University of Athens, 12462 Athens, GreeceNephrology Department, University Hospital of Ioannina, Stavros Niarchos Ave., 45500 Ioannina, GreeceDepartment of Endocrinology and Metabolic Diseases, Medical School, Larissa University Hospital, University of Thessaly, 41334 Larissa, Greece2nd University Department of Obstetrics & Gynecology, “Aretaieion” University Hospital, Medical School of Athens, Ethnikon and Kapodistriakon University of Athens, 12462 Athens, Greece2nd University Department of Obstetrics & Gynecology, “Aretaieion” University Hospital, Medical School of Athens, Ethnikon and Kapodistriakon University of Athens, 12462 Athens, GreeceEndocrine Unit, 2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, “Aretaieion” University Hospital, 11528 Athens, GreeceFetal exposure in adverse environmental factors during intrauterine life can lead to various biological adjustments, affecting not only in utero development of the conceptus, but also its later metabolic and endocrine wellbeing. During human gestation, maternal bone turnover increases, as reflected by molecules involved in bone metabolism, such as vitamin D, osteocalcin, sclerostin, sRANKL, and osteoprotegerin; however, recent studies support their emerging role in endocrine functions and glucose homeostasis regulation. Herein, we sought to systematically review current knowledge on the effects of aforementioned maternal bone biomarkers during pregnancy on fetal intrauterine growth and metabolism, neonatal anthropometric measures at birth, as well as on future endocrine and metabolic wellbeing of the offspring. A growing body of literature converges on the view that maternal bone turnover is likely implicated in fetal growth, and at least to some extent, in neonatal and childhood body composition and metabolic wellbeing. Maternal sclerostin and sRANKL are positively linked with fetal abdominal circumference and subcutaneous fat deposition, contributing to greater birthweights. Vitamin D deficiency correlates with lower birthweights, while research is still needed on intrauterine fetal metabolism, as well as on vitamin D dosing supplementation during pregnancy, to diminish the risks of low birthweight or SGA neonates in high-risk populations.https://www.mdpi.com/1422-0067/23/15/8328vitamin DsclerostinosteocalcinsRANKLbone metabolismfetal growth |
| spellingShingle | Angelos Dimas Anastasia Politi Alexandra Bargiota Theodoros Panoskaltsis Nikolaos F. Vlahos Georgios Valsamakis The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review International Journal of Molecular Sciences vitamin D sclerostin osteocalcin sRANKL bone metabolism fetal growth |
| title | The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review |
| title_full | The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review |
| title_fullStr | The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review |
| title_full_unstemmed | The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review |
| title_short | The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review |
| title_sort | gestational effects of maternal bone marker molecules on fetal growth metabolism and long term metabolic health a systematic review |
| topic | vitamin D sclerostin osteocalcin sRANKL bone metabolism fetal growth |
| url | https://www.mdpi.com/1422-0067/23/15/8328 |
| work_keys_str_mv | AT angelosdimas thegestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT anastasiapoliti thegestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT alexandrabargiota thegestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT theodorospanoskaltsis thegestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT nikolaosfvlahos thegestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT georgiosvalsamakis thegestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT angelosdimas gestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT anastasiapoliti gestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT alexandrabargiota gestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT theodorospanoskaltsis gestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT nikolaosfvlahos gestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview AT georgiosvalsamakis gestationaleffectsofmaternalbonemarkermoleculesonfetalgrowthmetabolismandlongtermmetabolichealthasystematicreview |