Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species.
The use of chemotherapeutics as a possible treatment strategy in avian oncology is steadily increasing over the last years. Despite this, literature reports regarding dosing strategies and pharmacokinetic behaviour of chemotherapeutics in avian species are lacking. The aim of the present study was t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4519271?pdf=render |
| _version_ | 1811343627379539968 |
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| author | Gunther Antonissen Mathias Devreese Siegrid De Baere Tom Hellebuyck Isabel Van de Maele Lieze Rouffaer Hendrickus J J Stemkens Patrick De Backer An Martel Siska Croubels |
| author_facet | Gunther Antonissen Mathias Devreese Siegrid De Baere Tom Hellebuyck Isabel Van de Maele Lieze Rouffaer Hendrickus J J Stemkens Patrick De Backer An Martel Siska Croubels |
| author_sort | Gunther Antonissen |
| collection | DOAJ |
| description | The use of chemotherapeutics as a possible treatment strategy in avian oncology is steadily increasing over the last years. Despite this, literature reports regarding dosing strategies and pharmacokinetic behaviour of chemotherapeutics in avian species are lacking. The aim of the present study was to investigate the pharmacokinetics of carboplatin in a representative species of the order of Galliformes, Anseriformes, Columbiformes and Psittaciformes. Eight chickens, ducks and pigeons and twenty-eight parakeets were administered carboplatin intravenously (5 mg/kg body weight). A specific and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for quantification of the free carboplatin in plasma of the four birds species (limit of quantification: 20 ng/mL for chicken and duck, 50 ng/mL for pigeon and 100 ng/mL for parakeets). Non-compartmental pharmacokinetic analysis and allometric scaling demonstrated a significant correlation (R² = 0.9769) between body weight (BW) and elimination half-life (T1/2el). T1/2el ranged from 0.41 h in parakeets (BW: 61 ± 8 g) to 1.16 h chickens (BW: 1909 ± 619 g). T1/2el is a good parameter for dose optimization of carboplatin in other avian species, since also the previously reported T1/2el in cockatoos (average BW: 769 ± 68 g) of 1.00 h corresponds to the results obtained in the present study. |
| first_indexed | 2024-04-13T19:32:16Z |
| format | Article |
| id | doaj.art-4fb1c11eda1542138f79e7cd11f78e3d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T19:32:16Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4fb1c11eda1542138f79e7cd11f78e3d2022-12-22T02:33:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013417710.1371/journal.pone.0134177Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species.Gunther AntonissenMathias DevreeseSiegrid De BaereTom HellebuyckIsabel Van de MaeleLieze RouffaerHendrickus J J StemkensPatrick De BackerAn MartelSiska CroubelsThe use of chemotherapeutics as a possible treatment strategy in avian oncology is steadily increasing over the last years. Despite this, literature reports regarding dosing strategies and pharmacokinetic behaviour of chemotherapeutics in avian species are lacking. The aim of the present study was to investigate the pharmacokinetics of carboplatin in a representative species of the order of Galliformes, Anseriformes, Columbiformes and Psittaciformes. Eight chickens, ducks and pigeons and twenty-eight parakeets were administered carboplatin intravenously (5 mg/kg body weight). A specific and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for quantification of the free carboplatin in plasma of the four birds species (limit of quantification: 20 ng/mL for chicken and duck, 50 ng/mL for pigeon and 100 ng/mL for parakeets). Non-compartmental pharmacokinetic analysis and allometric scaling demonstrated a significant correlation (R² = 0.9769) between body weight (BW) and elimination half-life (T1/2el). T1/2el ranged from 0.41 h in parakeets (BW: 61 ± 8 g) to 1.16 h chickens (BW: 1909 ± 619 g). T1/2el is a good parameter for dose optimization of carboplatin in other avian species, since also the previously reported T1/2el in cockatoos (average BW: 769 ± 68 g) of 1.00 h corresponds to the results obtained in the present study.http://europepmc.org/articles/PMC4519271?pdf=render |
| spellingShingle | Gunther Antonissen Mathias Devreese Siegrid De Baere Tom Hellebuyck Isabel Van de Maele Lieze Rouffaer Hendrickus J J Stemkens Patrick De Backer An Martel Siska Croubels Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species. PLoS ONE |
| title | Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species. |
| title_full | Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species. |
| title_fullStr | Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species. |
| title_full_unstemmed | Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species. |
| title_short | Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species. |
| title_sort | comparative pharmacokinetics and allometric scaling of carboplatin in different avian species |
| url | http://europepmc.org/articles/PMC4519271?pdf=render |
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