Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells

The neural crest is induced at the border between the neural plate and the epidermis. A complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. Here we discuss evidence supporting a model for neural crest induction in which different si...

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Main Authors: MANUEL J. AYBAR, ALVARO GLAVIC, ROBERTO MAYOR
Format: Article
Language:English
Published: BMC 2002-01-01
Series:Biological Research
Subjects:
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200018
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author MANUEL J. AYBAR
ALVARO GLAVIC
ROBERTO MAYOR
author_facet MANUEL J. AYBAR
ALVARO GLAVIC
ROBERTO MAYOR
author_sort MANUEL J. AYBAR
collection DOAJ
description The neural crest is induced at the border between the neural plate and the epidermis. A complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. Here we discuss evidence supporting a model for neural crest induction in which different signals contribute in a sequential order. First, a gradient of bone morphogenic proteins (BMPs) is established in the ectoderm that results in segreggation into neural plate, neural folds and epidermis at increasing levels of BMP activity. Thus, the neural folds are induced at a precise threshold concentration of BMP, but this neural fold has an anterior character. In a second step, these anterior neural folds are transformed into prospective neural crest by posteriorizing signals due to fibroblast growth factor, Wnts and retinoic acid. Finally, the induced cells interact to complete neural crest induction by a process that requires Notch/Delta signaling. Once neural crest formation has been induced by this combination of extracellular and intracellular signals, a cascade of transcription factors is activated in these cells that culminates in the ultimate steps of neural crest differentiation
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spelling doaj.art-4fb414f620ee4be6a73e527a149e181b2022-12-21T20:45:56ZengBMCBiological Research0716-97600717-62872002-01-01352267275Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cellsMANUEL J. AYBARALVARO GLAVICROBERTO MAYORThe neural crest is induced at the border between the neural plate and the epidermis. A complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. Here we discuss evidence supporting a model for neural crest induction in which different signals contribute in a sequential order. First, a gradient of bone morphogenic proteins (BMPs) is established in the ectoderm that results in segreggation into neural plate, neural folds and epidermis at increasing levels of BMP activity. Thus, the neural folds are induced at a precise threshold concentration of BMP, but this neural fold has an anterior character. In a second step, these anterior neural folds are transformed into prospective neural crest by posteriorizing signals due to fibroblast growth factor, Wnts and retinoic acid. Finally, the induced cells interact to complete neural crest induction by a process that requires Notch/Delta signaling. Once neural crest formation has been induced by this combination of extracellular and intracellular signals, a cascade of transcription factors is activated in these cells that culminates in the ultimate steps of neural crest differentiationhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200018neural crestinductionBMPsWntsFGFretinoic acidNotch, delta
spellingShingle MANUEL J. AYBAR
ALVARO GLAVIC
ROBERTO MAYOR
Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
Biological Research
neural crest
induction
BMPs
Wnts
FGF
retinoic acid
Notch, delta
title Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
title_full Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
title_fullStr Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
title_full_unstemmed Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
title_short Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
title_sort extracellular signals cell interactions and transcription factors involved in the induction of the neural crest cells
topic neural crest
induction
BMPs
Wnts
FGF
retinoic acid
Notch, delta
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200018
work_keys_str_mv AT manueljaybar extracellularsignalscellinteractionsandtranscriptionfactorsinvolvedintheinductionoftheneuralcrestcells
AT alvaroglavic extracellularsignalscellinteractionsandtranscriptionfactorsinvolvedintheinductionoftheneuralcrestcells
AT robertomayor extracellularsignalscellinteractionsandtranscriptionfactorsinvolvedintheinductionoftheneuralcrestcells