Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
The neural crest is induced at the border between the neural plate and the epidermis. A complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. Here we discuss evidence supporting a model for neural crest induction in which different si...
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Format: | Article |
Language: | English |
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BMC
2002-01-01
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Series: | Biological Research |
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Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200018 |
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author | MANUEL J. AYBAR ALVARO GLAVIC ROBERTO MAYOR |
author_facet | MANUEL J. AYBAR ALVARO GLAVIC ROBERTO MAYOR |
author_sort | MANUEL J. AYBAR |
collection | DOAJ |
description | The neural crest is induced at the border between the neural plate and the epidermis. A complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. Here we discuss evidence supporting a model for neural crest induction in which different signals contribute in a sequential order. First, a gradient of bone morphogenic proteins (BMPs) is established in the ectoderm that results in segreggation into neural plate, neural folds and epidermis at increasing levels of BMP activity. Thus, the neural folds are induced at a precise threshold concentration of BMP, but this neural fold has an anterior character. In a second step, these anterior neural folds are transformed into prospective neural crest by posteriorizing signals due to fibroblast growth factor, Wnts and retinoic acid. Finally, the induced cells interact to complete neural crest induction by a process that requires Notch/Delta signaling. Once neural crest formation has been induced by this combination of extracellular and intracellular signals, a cascade of transcription factors is activated in these cells that culminates in the ultimate steps of neural crest differentiation |
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id | doaj.art-4fb414f620ee4be6a73e527a149e181b |
institution | Directory Open Access Journal |
issn | 0716-9760 0717-6287 |
language | English |
last_indexed | 2024-12-19T00:12:59Z |
publishDate | 2002-01-01 |
publisher | BMC |
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series | Biological Research |
spelling | doaj.art-4fb414f620ee4be6a73e527a149e181b2022-12-21T20:45:56ZengBMCBiological Research0716-97600717-62872002-01-01352267275Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cellsMANUEL J. AYBARALVARO GLAVICROBERTO MAYORThe neural crest is induced at the border between the neural plate and the epidermis. A complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. Here we discuss evidence supporting a model for neural crest induction in which different signals contribute in a sequential order. First, a gradient of bone morphogenic proteins (BMPs) is established in the ectoderm that results in segreggation into neural plate, neural folds and epidermis at increasing levels of BMP activity. Thus, the neural folds are induced at a precise threshold concentration of BMP, but this neural fold has an anterior character. In a second step, these anterior neural folds are transformed into prospective neural crest by posteriorizing signals due to fibroblast growth factor, Wnts and retinoic acid. Finally, the induced cells interact to complete neural crest induction by a process that requires Notch/Delta signaling. Once neural crest formation has been induced by this combination of extracellular and intracellular signals, a cascade of transcription factors is activated in these cells that culminates in the ultimate steps of neural crest differentiationhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200018neural crestinductionBMPsWntsFGFretinoic acidNotch, delta |
spellingShingle | MANUEL J. AYBAR ALVARO GLAVIC ROBERTO MAYOR Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells Biological Research neural crest induction BMPs Wnts FGF retinoic acid Notch, delta |
title | Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells |
title_full | Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells |
title_fullStr | Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells |
title_full_unstemmed | Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells |
title_short | Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells |
title_sort | extracellular signals cell interactions and transcription factors involved in the induction of the neural crest cells |
topic | neural crest induction BMPs Wnts FGF retinoic acid Notch, delta |
url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200018 |
work_keys_str_mv | AT manueljaybar extracellularsignalscellinteractionsandtranscriptionfactorsinvolvedintheinductionoftheneuralcrestcells AT alvaroglavic extracellularsignalscellinteractionsandtranscriptionfactorsinvolvedintheinductionoftheneuralcrestcells AT robertomayor extracellularsignalscellinteractionsandtranscriptionfactorsinvolvedintheinductionoftheneuralcrestcells |