Epidemiological analysis of Group A streptococcus infection diseases among children in Beijing, China under COVID-19 pandemic
Abstract Background Group A streptococcus is human-restricted gram-positive pathogen, responsible for various clinical presentations from mild epidermis infections to life threatened invasive diseases. Under COVID-19 pandemic,. the characteristics of the epidemic strains of GAS could be different. P...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-023-03885-7 |
| _version_ | 1797863532108185600 |
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| author | Hongxin Li Lin Zhou Yong Zhao Lijuan Ma Haihua Zhang Yan Liu Xiaoyan Liu Jin Hu |
| author_facet | Hongxin Li Lin Zhou Yong Zhao Lijuan Ma Haihua Zhang Yan Liu Xiaoyan Liu Jin Hu |
| author_sort | Hongxin Li |
| collection | DOAJ |
| description | Abstract Background Group A streptococcus is human-restricted gram-positive pathogen, responsible for various clinical presentations from mild epidermis infections to life threatened invasive diseases. Under COVID-19 pandemic,. the characteristics of the epidemic strains of GAS could be different. Purpose To investigate epidemiological and molecular features of isolates from GAS infections among children in Beijing, China between January 2020 and December 2021. Antimicrobial susceptibility profiling was performed based on Cinical Laboratory Sandards Institute. Distribution of macrolide-resistance genes, emm types, and superantigens was examined by polymerase chain reaction. Results 114 GAS isolates were collected which were frequent resistance against erythromycin (94.74%), followed by clindamycin (92.98%), tetracycline (87.72%). Emm12 (46.49%), emm1 (25.44%) were dominant emm types. Distribution of ermB, ermA, and mefA gene was 93.85%, 2.63%, and 14.04%, respectively. Frequent superantigenes identified were smeZ (97.39%), speG (95.65%), and speC (92.17%). Emm1 strains possessed smeZ, ssa, and speC, while emm12 possessed smeZ, ssa, speG, and speC. Erythromycin resistance was predominantly mediated by ermB. Scarlet fever strains harbored smeZ (98.81%), speC (94.05%). Impetigo strains harbored smeZ (88.98%), ssa (88.89%), and speC (88.89%). Psoriasis strains harbored smeZ (100%). Conclusions Under COVID-19 pandemic, our collections of GAS infection cutaneous diseases decreased dramatically. Epidemiological analysis of GAS infections among children during COVID-19 pandemic was not significantly different from our previous study. There was a correlation among emm, superantigen gene and disease manifestations. Long-term surveillance and investigation of emm types and superantigens of GAS prevalence are imperative. |
| first_indexed | 2024-04-09T22:37:00Z |
| format | Article |
| id | doaj.art-4fb4e709a3e845b3bf71e8cdc950fdad |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-04-09T22:37:00Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-4fb4e709a3e845b3bf71e8cdc950fdad2023-03-22T12:24:16ZengBMCBMC Pediatrics1471-24312023-02-0123111010.1186/s12887-023-03885-7Epidemiological analysis of Group A streptococcus infection diseases among children in Beijing, China under COVID-19 pandemicHongxin Li0Lin Zhou1Yong Zhao2Lijuan Ma3Haihua Zhang4Yan Liu5Xiaoyan Liu6Jin Hu7Department of Dermatology, Children’s Hospital Affiliated to Capital Institute of PediatricsDepartment of Clinical Laboratory, Children’s Hospital Affiliated to Capital Institute of PediatricsDepartment of Reproductive Medicine, Senior Department of Obstetrics & Gynecology, The Seventh Medical Center of PLA General HospitalDepartment of Clinical Laboratory, Children’s Hospital Affiliated to Capital Institute of PediatricsDepartment of Dermatology, Children’s Hospital Affiliated to Capital Institute of PediatricsDepartment of Dermatology, Children’s Hospital Affiliated to Capital Institute of PediatricsDepartment of Dermatology, Children’s Hospital Affiliated to Capital Institute of PediatricsDepartment of Dermatology, Children’s Hospital Affiliated to Capital Institute of PediatricsAbstract Background Group A streptococcus is human-restricted gram-positive pathogen, responsible for various clinical presentations from mild epidermis infections to life threatened invasive diseases. Under COVID-19 pandemic,. the characteristics of the epidemic strains of GAS could be different. Purpose To investigate epidemiological and molecular features of isolates from GAS infections among children in Beijing, China between January 2020 and December 2021. Antimicrobial susceptibility profiling was performed based on Cinical Laboratory Sandards Institute. Distribution of macrolide-resistance genes, emm types, and superantigens was examined by polymerase chain reaction. Results 114 GAS isolates were collected which were frequent resistance against erythromycin (94.74%), followed by clindamycin (92.98%), tetracycline (87.72%). Emm12 (46.49%), emm1 (25.44%) were dominant emm types. Distribution of ermB, ermA, and mefA gene was 93.85%, 2.63%, and 14.04%, respectively. Frequent superantigenes identified were smeZ (97.39%), speG (95.65%), and speC (92.17%). Emm1 strains possessed smeZ, ssa, and speC, while emm12 possessed smeZ, ssa, speG, and speC. Erythromycin resistance was predominantly mediated by ermB. Scarlet fever strains harbored smeZ (98.81%), speC (94.05%). Impetigo strains harbored smeZ (88.98%), ssa (88.89%), and speC (88.89%). Psoriasis strains harbored smeZ (100%). Conclusions Under COVID-19 pandemic, our collections of GAS infection cutaneous diseases decreased dramatically. Epidemiological analysis of GAS infections among children during COVID-19 pandemic was not significantly different from our previous study. There was a correlation among emm, superantigen gene and disease manifestations. Long-term surveillance and investigation of emm types and superantigens of GAS prevalence are imperative.https://doi.org/10.1186/s12887-023-03885-7Group A streptococcusEmm typeSuperantigenAntimicrobial resistanceScarlet feverChildren |
| spellingShingle | Hongxin Li Lin Zhou Yong Zhao Lijuan Ma Haihua Zhang Yan Liu Xiaoyan Liu Jin Hu Epidemiological analysis of Group A streptococcus infection diseases among children in Beijing, China under COVID-19 pandemic BMC Pediatrics Group A streptococcus Emm type Superantigen Antimicrobial resistance Scarlet fever Children |
| title | Epidemiological analysis of Group A streptococcus infection diseases among children in Beijing, China under COVID-19 pandemic |
| title_full | Epidemiological analysis of Group A streptococcus infection diseases among children in Beijing, China under COVID-19 pandemic |
| title_fullStr | Epidemiological analysis of Group A streptococcus infection diseases among children in Beijing, China under COVID-19 pandemic |
| title_full_unstemmed | Epidemiological analysis of Group A streptococcus infection diseases among children in Beijing, China under COVID-19 pandemic |
| title_short | Epidemiological analysis of Group A streptococcus infection diseases among children in Beijing, China under COVID-19 pandemic |
| title_sort | epidemiological analysis of group a streptococcus infection diseases among children in beijing china under covid 19 pandemic |
| topic | Group A streptococcus Emm type Superantigen Antimicrobial resistance Scarlet fever Children |
| url | https://doi.org/10.1186/s12887-023-03885-7 |
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