Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study
ABSTRACT Objective In this study, we employed a Mendelian randomization (MR) approach to investigate the independent causal associations of six body composition traits with gestational diabetes mellitus (GDM). Methods Genome‐wide significant levels (P < 10 × 5−8) of single nucleotide polymorphism...
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.14115 |
| _version_ | 1827337779018727424 |
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| author | Yuan Gao Min Zhou Xuan Xu Jun Yang Ma Man Fen Qin |
| author_facet | Yuan Gao Min Zhou Xuan Xu Jun Yang Ma Man Fen Qin |
| author_sort | Yuan Gao |
| collection | DOAJ |
| description | ABSTRACT Objective In this study, we employed a Mendelian randomization (MR) approach to investigate the independent causal associations of six body composition traits with gestational diabetes mellitus (GDM). Methods Genome‐wide significant levels (P < 10 × 5−8) of single nucleotide polymorphisms associated with body water mass, total protein, whole body fat‐free mass, weight, whole body fat mass, and body fat percentage were used as instrumental variables. Data on GDM were obtained from the FinnGen Consortium, and both univariable and multivariable Mendelian randomization were performed. We utilized five different analytical methods including inverse‐variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode to assess the robustness of the results. Results With univariable Mendelian randomization, the risk of GDM increased per 1‐standard deviation (SD) increase in weight (ORweight = 1.297, P = 3.06 × 10−5), whole body fat mass (ORwhole body fat mass = 1.408, P = 1.32 × 10−6), and the risk of GDM increased per percent increase in body fat percentage (ORbody fat percentage = 1.661, P = 1.01 × 10−8). Total protein had a protective effect on the risk of GDM (ORtotal protein = 0.880, P = 0.048). However, there was no significant causal association between increases in body water mass and whole body fat‐free mass per SD and the risk of GDM. Causal associations between weight, whole body fat mass, body fat percentage, and total protein with GDM were reduced to null in multivariable Mendelian randomization. Conclusion The present study furnishes genetic evidence to elucidate the causal relationship between body composition traits and GDM. Additionally, further studies are imperative to establish a causal connection between body composition traits and gestational diabetes mellitus. |
| first_indexed | 2024-03-07T19:02:17Z |
| format | Article |
| id | doaj.art-4fb4e745e1af4501ae896186f821d86e |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-03-07T19:02:17Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-4fb4e745e1af4501ae896186f821d86e2024-03-01T12:52:01ZengWileyJournal of Diabetes Investigation2040-11162040-11242024-03-0115334635410.1111/jdi.14115Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization studyYuan Gao0Min Zhou1Xuan Xu2Jun Yang Ma3Man Fen Qin4The Second Affiliated Hospital of Nanchang University Nanchang ChinaThe Second Affiliated Hospital of Nanchang University Nanchang ChinaThe Second Affiliated Hospital of Nanchang University Nanchang ChinaSchool of Clinical Medicine Jining Medical University Jining ChinaThe Second Affiliated Hospital of Nanchang University Nanchang ChinaABSTRACT Objective In this study, we employed a Mendelian randomization (MR) approach to investigate the independent causal associations of six body composition traits with gestational diabetes mellitus (GDM). Methods Genome‐wide significant levels (P < 10 × 5−8) of single nucleotide polymorphisms associated with body water mass, total protein, whole body fat‐free mass, weight, whole body fat mass, and body fat percentage were used as instrumental variables. Data on GDM were obtained from the FinnGen Consortium, and both univariable and multivariable Mendelian randomization were performed. We utilized five different analytical methods including inverse‐variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode to assess the robustness of the results. Results With univariable Mendelian randomization, the risk of GDM increased per 1‐standard deviation (SD) increase in weight (ORweight = 1.297, P = 3.06 × 10−5), whole body fat mass (ORwhole body fat mass = 1.408, P = 1.32 × 10−6), and the risk of GDM increased per percent increase in body fat percentage (ORbody fat percentage = 1.661, P = 1.01 × 10−8). Total protein had a protective effect on the risk of GDM (ORtotal protein = 0.880, P = 0.048). However, there was no significant causal association between increases in body water mass and whole body fat‐free mass per SD and the risk of GDM. Causal associations between weight, whole body fat mass, body fat percentage, and total protein with GDM were reduced to null in multivariable Mendelian randomization. Conclusion The present study furnishes genetic evidence to elucidate the causal relationship between body composition traits and GDM. Additionally, further studies are imperative to establish a causal connection between body composition traits and gestational diabetes mellitus.https://doi.org/10.1111/jdi.14115Body compositionGestational diabetes mellitusMendelian randomization |
| spellingShingle | Yuan Gao Min Zhou Xuan Xu Jun Yang Ma Man Fen Qin Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study Journal of Diabetes Investigation Body composition Gestational diabetes mellitus Mendelian randomization |
| title | Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study |
| title_full | Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study |
| title_fullStr | Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study |
| title_full_unstemmed | Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study |
| title_short | Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study |
| title_sort | body composition and risk of gestational diabetes mellitus a univariable and multivariable mendelian randomization study |
| topic | Body composition Gestational diabetes mellitus Mendelian randomization |
| url | https://doi.org/10.1111/jdi.14115 |
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