Circulating PCSK9 and Risk of Myocardial Infarction
The usefulness of circulating proprotein convertase subtilisin-kexin type 9 (PCSK9) as a risk marker of coronary heart disease in the general population remains unclear. In a nested case-control study in Norway, 1,488 incident myocardial infarctions were registered during 11.3 years of follow-up and...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-12-01
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| Series: | JACC: Basic to Translational Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452302X16300997 |
| _version_ | 1819137975310614528 |
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| author | Lars E. Laugsand, MD, PhD Bjørn O. Åsvold, MD, PhD Lars J. Vatten, MD, PhD Imre Janszky, MD, PhD Carl G. Platou, MD Annika E. Michelsen, PhD Jan K. Damås, MD, PhD Pål Aukrust, MD, PhD Thor Ueland, PhD |
| author_facet | Lars E. Laugsand, MD, PhD Bjørn O. Åsvold, MD, PhD Lars J. Vatten, MD, PhD Imre Janszky, MD, PhD Carl G. Platou, MD Annika E. Michelsen, PhD Jan K. Damås, MD, PhD Pål Aukrust, MD, PhD Thor Ueland, PhD |
| author_sort | Lars E. Laugsand, MD, PhD |
| collection | DOAJ |
| description | The usefulness of circulating proprotein convertase subtilisin-kexin type 9 (PCSK9) as a risk marker of coronary heart disease in the general population remains unclear. In a nested case-control study in Norway, 1,488 incident myocardial infarctions were registered during 11.3 years of follow-up and compared with 3,819 controls. Compared with participants in the lowest quartile of PCSK9, myocardial infarction risk was 47% higher in the highest quartile after adjustment for age and sex. After additional adjustment for low-density lipoprotein cholesterol, the association was strongly attenuated. Thus, circulating PCSK9 does not contribute useful information in the assessment of myocardial infarction risk in the general population beyond the information provided by lipid measurements. |
| first_indexed | 2024-12-22T10:59:25Z |
| format | Article |
| id | doaj.art-4fb5643c1f15420aa88554209e7fcc9a |
| institution | Directory Open Access Journal |
| issn | 2452-302X |
| language | English |
| last_indexed | 2024-12-22T10:59:25Z |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Basic to Translational Science |
| spelling | doaj.art-4fb5643c1f15420aa88554209e7fcc9a2022-12-21T18:28:32ZengElsevierJACC: Basic to Translational Science2452-302X2016-12-011756857510.1016/j.jacbts.2016.06.007Circulating PCSK9 and Risk of Myocardial InfarctionLars E. Laugsand, MD, PhD0Bjørn O. Åsvold, MD, PhD1Lars J. Vatten, MD, PhD2Imre Janszky, MD, PhD3Carl G. Platou, MD4Annika E. Michelsen, PhD5Jan K. Damås, MD, PhD6Pål Aukrust, MD, PhD7Thor Ueland, PhD8Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, NorwayResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, NorwayCentre of Molecular Inflammation Research, Oslo University Hospital, Rikshospitalet, Oslo, NorwayResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, NorwayResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, NorwayThe usefulness of circulating proprotein convertase subtilisin-kexin type 9 (PCSK9) as a risk marker of coronary heart disease in the general population remains unclear. In a nested case-control study in Norway, 1,488 incident myocardial infarctions were registered during 11.3 years of follow-up and compared with 3,819 controls. Compared with participants in the lowest quartile of PCSK9, myocardial infarction risk was 47% higher in the highest quartile after adjustment for age and sex. After additional adjustment for low-density lipoprotein cholesterol, the association was strongly attenuated. Thus, circulating PCSK9 does not contribute useful information in the assessment of myocardial infarction risk in the general population beyond the information provided by lipid measurements.http://www.sciencedirect.com/science/article/pii/S2452302X16300997PCSK9 inflammationepidemiologymyocardial infarctionprospective studyrisk factors |
| spellingShingle | Lars E. Laugsand, MD, PhD Bjørn O. Åsvold, MD, PhD Lars J. Vatten, MD, PhD Imre Janszky, MD, PhD Carl G. Platou, MD Annika E. Michelsen, PhD Jan K. Damås, MD, PhD Pål Aukrust, MD, PhD Thor Ueland, PhD Circulating PCSK9 and Risk of Myocardial Infarction JACC: Basic to Translational Science PCSK9 inflammation epidemiology myocardial infarction prospective study risk factors |
| title | Circulating PCSK9 and Risk of Myocardial Infarction |
| title_full | Circulating PCSK9 and Risk of Myocardial Infarction |
| title_fullStr | Circulating PCSK9 and Risk of Myocardial Infarction |
| title_full_unstemmed | Circulating PCSK9 and Risk of Myocardial Infarction |
| title_short | Circulating PCSK9 and Risk of Myocardial Infarction |
| title_sort | circulating pcsk9 and risk of myocardial infarction |
| topic | PCSK9 inflammation epidemiology myocardial infarction prospective study risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S2452302X16300997 |
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