Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes

Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes

2,4-Dinitrophenol (DNP) is a classic uncoupler of oxidative phosphorylation in mitochondria which is still used in “diet pills”, despite its high toxicity and lack of antidotes. DNP increases the proton current through pure lipid membranes, similar to other chemical uncouplers. However, the molecula...

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Bibliographic Details
Main Authors: Kristina Žuna, Olga Jovanović, Ljudmila S. Khailova, Sanja Škulj, Zlatko Brkljača, Jürgen Kreiter, Elena A. Kotova, Mario Vazdar, Yuri N. Antonenko, Elena E. Pohl
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomolecules
Subjects:
mitochondrial uncoupler
protonophore
membrane potential
proton conductance
artificial membranes
molecular dynamics simulations
Online Access:https://www.mdpi.com/2218-273X/11/8/1178

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