Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer
It was proven that PGK1 plays a vital role in the proliferation, migration, and invasion of human breast cancer. However, the correlation of PGK1 mRNA and protein expression with clinicopathologic characteristics and prognostic values according to various kinds of breast cancer patient classificatio...
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| Format: | Article |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.695420/full |
| _version_ | 1818458675111526400 |
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| author | Yanping Li Shanshan Wang Xiaoyuan Zhang Rui Yang Xiaonan Wei Ruirong Yan Yaru Jiang Wenzhi Shen Wenzhi Shen |
| author_facet | Yanping Li Shanshan Wang Xiaoyuan Zhang Rui Yang Xiaonan Wei Ruirong Yan Yaru Jiang Wenzhi Shen Wenzhi Shen |
| author_sort | Yanping Li |
| collection | DOAJ |
| description | It was proven that PGK1 plays a vital role in the proliferation, migration, and invasion of human breast cancer. However, the correlation of PGK1 mRNA and protein expression with clinicopathologic characteristics and prognostic values according to various kinds of breast cancer patient classifications remains unsufficient. Here, we analyzed data from the Oncomine database, Breast cancer Gene-Expression Miner v4.5, TNMplot, MuTarget, PrognoScan database, and clinical bioinformatics to investigate PGK1 expression distribution and prognostic value in breast cancer patients. Our study revealed that the mRNA and protein expression levels of PGK1 were up-regulated in various clinicopathologic types of breast cancer. Moreover, the expression of PGK1 was correlated with mutations of common tumor suppressor genes TP53 and CDH1. In addition, we found that high mRNA level of PGK1 was significantly associated with poor OS, RFS, and DMFS. Notably, Cox regressionanalysis showed that PGK1 could be used as an independent prognostic marker. In summary, the aforementioned findings suggested that PGK1 might be not only explored as a potential biomarker, but also combined with TP53/CDH1 for chemotherapy in breast cancer. |
| first_indexed | 2024-12-14T23:02:13Z |
| format | Article |
| id | doaj.art-4fb74cb08dd64f049c06748c4d63141e |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-14T23:02:13Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-4fb74cb08dd64f049c06748c4d63141e2022-12-21T22:44:26ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-07-01810.3389/fmolb.2021.695420695420Expression Characteristics and Significant Prognostic Values of PGK1 in Breast CancerYanping Li0Shanshan Wang1Xiaoyuan Zhang2Rui Yang3Xiaonan Wei4Ruirong Yan5Yaru Jiang6Wenzhi Shen7Wenzhi Shen8Department of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, ChinaDepartment of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, ChinaDepartment of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, ChinaDepartment of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, ChinaDepartment of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, ChinaDepartment of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, ChinaDepartment of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, ChinaDepartment of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, ChinaInstitute of Breast Research, Jining Medical University, Jining, ChinaIt was proven that PGK1 plays a vital role in the proliferation, migration, and invasion of human breast cancer. However, the correlation of PGK1 mRNA and protein expression with clinicopathologic characteristics and prognostic values according to various kinds of breast cancer patient classifications remains unsufficient. Here, we analyzed data from the Oncomine database, Breast cancer Gene-Expression Miner v4.5, TNMplot, MuTarget, PrognoScan database, and clinical bioinformatics to investigate PGK1 expression distribution and prognostic value in breast cancer patients. Our study revealed that the mRNA and protein expression levels of PGK1 were up-regulated in various clinicopathologic types of breast cancer. Moreover, the expression of PGK1 was correlated with mutations of common tumor suppressor genes TP53 and CDH1. In addition, we found that high mRNA level of PGK1 was significantly associated with poor OS, RFS, and DMFS. Notably, Cox regressionanalysis showed that PGK1 could be used as an independent prognostic marker. In summary, the aforementioned findings suggested that PGK1 might be not only explored as a potential biomarker, but also combined with TP53/CDH1 for chemotherapy in breast cancer.https://www.frontiersin.org/articles/10.3389/fmolb.2021.695420/fullPGK1breast cancerprognosticpublic databasesprognostic valuecomprehensive analysis 3 |
| spellingShingle | Yanping Li Shanshan Wang Xiaoyuan Zhang Rui Yang Xiaonan Wei Ruirong Yan Yaru Jiang Wenzhi Shen Wenzhi Shen Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer Frontiers in Molecular Biosciences PGK1 breast cancer prognostic public databases prognostic value comprehensive analysis 3 |
| title | Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer |
| title_full | Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer |
| title_fullStr | Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer |
| title_full_unstemmed | Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer |
| title_short | Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer |
| title_sort | expression characteristics and significant prognostic values of pgk1 in breast cancer |
| topic | PGK1 breast cancer prognostic public databases prognostic value comprehensive analysis 3 |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.695420/full |
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