A simplified T classification based on the 8th edition of the UICC/AJCC staging system for nasopharyngeal carcinoma
Xing-Xi Pan,1 Li-Hua Tong,1 Yong-Fa Chen,1 Fei-Long Li,1 Wu-Bing Tang,1 Ya-Jie Liu,2 Wen Yang11Department of Oncology, Nanhai Hospital Affiliated to Southern Medical University, Foshan, Guangdong 528200, People’s Republic of China; 2Department of Oncology, Peking University Shenzhen Hospit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-04-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/a-simplified-t-classification-based-on-the-8th-edition-of-the-uiccajcc-peer-reviewed-article-CMAR |
| _version_ | 1818600361013805056 |
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| author | Pan XX Tong LH Chen YF Li FL Tang WB Liu YJ Yang W |
| author_facet | Pan XX Tong LH Chen YF Li FL Tang WB Liu YJ Yang W |
| author_sort | Pan XX |
| collection | DOAJ |
| description | Xing-Xi Pan,1 Li-Hua Tong,1 Yong-Fa Chen,1 Fei-Long Li,1 Wu-Bing Tang,1 Ya-Jie Liu,2 Wen Yang11Department of Oncology, Nanhai Hospital Affiliated to Southern Medical University, Foshan, Guangdong 528200, People’s Republic of China; 2Department of Oncology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, People’s Republic of ChinaObjective: This study aimed to establish a simplified T classification based on the 8th edition of the Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) staging system for nasopharyngeal carcinoma (NPC).Methods: In total, 325 patients with NPC were included in this study. All patients underwent magnetic resonance imaging, and the staging criteria were recorded. These patients were subjected to staging with the 8th edition of the UICC/AJCC staging system for NPC.Results: Involvement of the oropharynx, nasal cavity, adjacent soft tissue (medial pterygoid, lateral pterygoid, and prevertebral muscles), cervical vertebra, orbit, and hypopharynx were always accompanied by other equivalently or more advanced T-stage classifications. All cases with involvement of the paranasal sinuses showed skull base erosion. The majority of cases with involvement of the pterygoid structure showed skull base erosion.Conclusion: According to the simplification principle, the following new T classification based on the 8th edition of the UICC/AJCC staging system was established: T1, tumor confined to nasopharynx, or beyond the nasopharynx without parapharyngeal involvement; T2, tumor with extension to the parapharyngeal space; T3, tumor with infiltration to bony structures at the skull base; T4, tumor with intracranial extension, involvement of the cranial nerves or parotid gland, and/or extensive soft tissue infiltration beyond the lateral surface of the lateral pterygoid muscle. Validation with a large series of patients is needed.Keywords: nasopharyngeal cancer, TNM staging system, T classification
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| first_indexed | 2024-12-16T12:34:16Z |
| format | Article |
| id | doaj.art-4fb7aff7d0ce4df889bf9940103890f1 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-16T12:34:16Z |
| publishDate | 2019-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-4fb7aff7d0ce4df889bf9940103890f12022-12-21T22:31:38ZengDove Medical PressCancer Management and Research1179-13222019-04-01Volume 113163316945059A simplified T classification based on the 8th edition of the UICC/AJCC staging system for nasopharyngeal carcinomaPan XXTong LHChen YFLi FLTang WBLiu YJYang WXing-Xi Pan,1 Li-Hua Tong,1 Yong-Fa Chen,1 Fei-Long Li,1 Wu-Bing Tang,1 Ya-Jie Liu,2 Wen Yang11Department of Oncology, Nanhai Hospital Affiliated to Southern Medical University, Foshan, Guangdong 528200, People’s Republic of China; 2Department of Oncology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, People’s Republic of ChinaObjective: This study aimed to establish a simplified T classification based on the 8th edition of the Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) staging system for nasopharyngeal carcinoma (NPC).Methods: In total, 325 patients with NPC were included in this study. All patients underwent magnetic resonance imaging, and the staging criteria were recorded. These patients were subjected to staging with the 8th edition of the UICC/AJCC staging system for NPC.Results: Involvement of the oropharynx, nasal cavity, adjacent soft tissue (medial pterygoid, lateral pterygoid, and prevertebral muscles), cervical vertebra, orbit, and hypopharynx were always accompanied by other equivalently or more advanced T-stage classifications. All cases with involvement of the paranasal sinuses showed skull base erosion. The majority of cases with involvement of the pterygoid structure showed skull base erosion.Conclusion: According to the simplification principle, the following new T classification based on the 8th edition of the UICC/AJCC staging system was established: T1, tumor confined to nasopharynx, or beyond the nasopharynx without parapharyngeal involvement; T2, tumor with extension to the parapharyngeal space; T3, tumor with infiltration to bony structures at the skull base; T4, tumor with intracranial extension, involvement of the cranial nerves or parotid gland, and/or extensive soft tissue infiltration beyond the lateral surface of the lateral pterygoid muscle. Validation with a large series of patients is needed.Keywords: nasopharyngeal cancer, TNM staging system, T classification https://www.dovepress.com/a-simplified-t-classification-based-on-the-8th-edition-of-the-uiccajcc-peer-reviewed-article-CMARNasopharyngeal cancerTNM staging systemT classification |
| spellingShingle | Pan XX Tong LH Chen YF Li FL Tang WB Liu YJ Yang W A simplified T classification based on the 8th edition of the UICC/AJCC staging system for nasopharyngeal carcinoma Cancer Management and Research Nasopharyngeal cancer TNM staging system T classification |
| title | A simplified T classification based on the 8th edition of the UICC/AJCC staging system for nasopharyngeal carcinoma |
| title_full | A simplified T classification based on the 8th edition of the UICC/AJCC staging system for nasopharyngeal carcinoma |
| title_fullStr | A simplified T classification based on the 8th edition of the UICC/AJCC staging system for nasopharyngeal carcinoma |
| title_full_unstemmed | A simplified T classification based on the 8th edition of the UICC/AJCC staging system for nasopharyngeal carcinoma |
| title_short | A simplified T classification based on the 8th edition of the UICC/AJCC staging system for nasopharyngeal carcinoma |
| title_sort | simplified t classification based on the 8th edition of the uicc ajcc staging system for nasopharyngeal carcinoma |
| topic | Nasopharyngeal cancer TNM staging system T classification |
| url | https://www.dovepress.com/a-simplified-t-classification-based-on-the-8th-edition-of-the-uiccajcc-peer-reviewed-article-CMAR |
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