Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells

Abstract Background Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application safety issues concerning a risk of potential neoplastic degeneration in a...

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Bibliographic Details
Main Authors: Svitlana Melnik, Nadine Werth, Stephane Boeuf, Eva-Maria Hahn, Tobias Gotterbarm, Martina Anton, Wiltrud Richter
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Stem Cell Research & Therapy
Subjects:
MYC
Mesenchymal stromal cells (MSC)
Osteogenesis
Adipogenesis
Chondrogenesis
Tumorigenesis
Online Access:http://link.springer.com/article/10.1186/s13287-019-1187-z

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http://link.springer.com/article/10.1186/s13287-019-1187-z

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