Tn-Seq reveals hidden complexity in the utilization of host-derived glutathione in Francisella tularensis.

Tn-Seq reveals hidden complexity in the utilization of host-derived glutathione in Francisella tularensis.

Host-derived glutathione (GSH) is an essential source of cysteine for the intracellular pathogen Francisella tularensis. In a comprehensive transposon insertion sequencing screen, we identified several F. tularensis genes that play central and previously unappreciated roles in the utilization of GSH...

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Bibliographic Details
Main Authors: Kathryn M Ramsey, Hannah E Ledvina, Tenayaann M Tresko, Jamie M Wandzilak, Catherine A Tower, Thomas Tallo, Caroline E Schramm, S Brook Peterson, Shawn J Skerrett, Joseph D Mougous, Simon L Dove
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008566

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