Comparative connectomics of dauer reveals developmental plasticity
Abstract A fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the chemical connectome of dauer, an alternative developmental stage of nematodes with distinct behavioral characteristics, by volumetric rec...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-45943-3 |
| _version_ | 1797274089478422528 |
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| author | Hyunsoo Yim Daniel T. Choe J. Alexander Bae Myung-kyu Choi Hae-Mook Kang Ken C. Q. Nguyen Soungyub Ahn Sang-kyu Bahn Heeseung Yang David H. Hall Jinseop S. Kim Junho Lee |
| author_facet | Hyunsoo Yim Daniel T. Choe J. Alexander Bae Myung-kyu Choi Hae-Mook Kang Ken C. Q. Nguyen Soungyub Ahn Sang-kyu Bahn Heeseung Yang David H. Hall Jinseop S. Kim Junho Lee |
| author_sort | Hyunsoo Yim |
| collection | DOAJ |
| description | Abstract A fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the chemical connectome of dauer, an alternative developmental stage of nematodes with distinct behavioral characteristics, by volumetric reconstruction and automated synapse detection using deep learning. With the basic architecture of the nervous system preserved, structural changes in neurons, large or small, were closely associated with connectivity changes, which in turn evoked dauer-specific behaviors such as nictation. Graph theoretical analyses revealed significant dauer-specific rewiring of sensory neuron connectivity and increased clustering within motor neurons in the dauer connectome. We suggest that the nervous system in the nematode has evolved to respond to harsh environments by developing a quantitatively and qualitatively differentiated connectome. |
| first_indexed | 2024-03-07T14:53:23Z |
| format | Article |
| id | doaj.art-4fb911b1c29c4b9683999d212272c371 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:53:23Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4fb911b1c29c4b9683999d212272c3712024-03-05T19:34:20ZengNature PortfolioNature Communications2041-17232024-02-0115111410.1038/s41467-024-45943-3Comparative connectomics of dauer reveals developmental plasticityHyunsoo Yim0Daniel T. Choe1J. Alexander Bae2Myung-kyu Choi3Hae-Mook Kang4Ken C. Q. Nguyen5Soungyub Ahn6Sang-kyu Bahn7Heeseung Yang8David H. Hall9Jinseop S. Kim10Junho Lee11Department of Biological Sciences, Seoul National UniversityDepartment of Biological Sciences, Seoul National UniversityResearch Institute of Basic Sciences, Seoul National UniversityResearch Institute of Basic Sciences, Seoul National UniversityResearch Institute of Basic Sciences, Seoul National UniversityDominick P. Purpura Department of Neuroscience, Albert Einstein College of MedicineDepartment of Biological Sciences, Seoul National UniversityNeural Circuits Research Group, Korea Brain Research InstituteDepartment of Biological Sciences, Seoul National UniversityDominick P. Purpura Department of Neuroscience, Albert Einstein College of MedicineNeural Circuits Research Group, Korea Brain Research InstituteDepartment of Biological Sciences, Seoul National UniversityAbstract A fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the chemical connectome of dauer, an alternative developmental stage of nematodes with distinct behavioral characteristics, by volumetric reconstruction and automated synapse detection using deep learning. With the basic architecture of the nervous system preserved, structural changes in neurons, large or small, were closely associated with connectivity changes, which in turn evoked dauer-specific behaviors such as nictation. Graph theoretical analyses revealed significant dauer-specific rewiring of sensory neuron connectivity and increased clustering within motor neurons in the dauer connectome. We suggest that the nervous system in the nematode has evolved to respond to harsh environments by developing a quantitatively and qualitatively differentiated connectome.https://doi.org/10.1038/s41467-024-45943-3 |
| spellingShingle | Hyunsoo Yim Daniel T. Choe J. Alexander Bae Myung-kyu Choi Hae-Mook Kang Ken C. Q. Nguyen Soungyub Ahn Sang-kyu Bahn Heeseung Yang David H. Hall Jinseop S. Kim Junho Lee Comparative connectomics of dauer reveals developmental plasticity Nature Communications |
| title | Comparative connectomics of dauer reveals developmental plasticity |
| title_full | Comparative connectomics of dauer reveals developmental plasticity |
| title_fullStr | Comparative connectomics of dauer reveals developmental plasticity |
| title_full_unstemmed | Comparative connectomics of dauer reveals developmental plasticity |
| title_short | Comparative connectomics of dauer reveals developmental plasticity |
| title_sort | comparative connectomics of dauer reveals developmental plasticity |
| url | https://doi.org/10.1038/s41467-024-45943-3 |
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