Association between atherosclerosis, hearing recovery, and hearing in the healthy ear in idiopathic sudden sensorineural hearing loss: a retrospective chart analysis
Abstract Atherosclerosis is reported to be a risk factor for the severity of idiopathic sudden sensorineural hearing loss (ISSNHL). We evaluated the hypothesis that atherosclerosis affects the hearing thresholds of both the affected and healthy sides of ISSNHL patients. We conducted multivariate ana...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25593-5 |
| _version_ | 1811291933424746496 |
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| author | Nobuyoshi Tsuzuki Koichiro Wasano Naoki Oishi Ko Hentona Marie Shimanuki Takanori Nishiyama Yoshihiko Hiraga Masafumi Ueno Narihisa Suzuki Seiichi Shinden Kaoru Ogawa Hiroyuki Ozawa |
| author_facet | Nobuyoshi Tsuzuki Koichiro Wasano Naoki Oishi Ko Hentona Marie Shimanuki Takanori Nishiyama Yoshihiko Hiraga Masafumi Ueno Narihisa Suzuki Seiichi Shinden Kaoru Ogawa Hiroyuki Ozawa |
| author_sort | Nobuyoshi Tsuzuki |
| collection | DOAJ |
| description | Abstract Atherosclerosis is reported to be a risk factor for the severity of idiopathic sudden sensorineural hearing loss (ISSNHL). We evaluated the hypothesis that atherosclerosis affects the hearing thresholds of both the affected and healthy sides of ISSNHL patients. We conducted multivariate analyses on retrospectively collected data of patients with ISSNHL (N = 762) to evaluate the relationship between known factors linked to atherosclerosis and hearing thresholds on affected and healthy sides and whether these factors are prognostic for hearing recovery. Older ages, vertigo or dizziness, diabetes mellitus, and congestive heart failure were significantly related to higher hearing thresholds on the affected side. Older ages, male, and vascular disease were significantly related to higher hearing thresholds on the healthy side. Vertigo or dizziness, severe hearing loss and hearing loss at high frequencies on the affected side, higher hearing thresholds on the healthy side, regular anticoagulant medication, and delayed steroid treatment were significantly related to lack of recovery. Since several atherosclerosis-related factors are associated with higher hearing thresholds on both affected and healthy sides in ISSNHL and higher hearing thresholds on the healthy side predict poorer prognosis, diagnosis, and predicting prognosis of ISSNHL may benefit from rigorous evaluation of patients’ cardiovascular comorbidities and hearing levels on both the healthy and affected sides. |
| first_indexed | 2024-04-13T04:37:41Z |
| format | Article |
| id | doaj.art-4fb946f09bc441b9a8698cd88f49b49b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T04:37:41Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4fb946f09bc441b9a8698cd88f49b49b2022-12-22T03:02:07ZengNature PortfolioScientific Reports2045-23222022-12-0112111110.1038/s41598-022-25593-5Association between atherosclerosis, hearing recovery, and hearing in the healthy ear in idiopathic sudden sensorineural hearing loss: a retrospective chart analysisNobuyoshi Tsuzuki0Koichiro Wasano1Naoki Oishi2Ko Hentona3Marie Shimanuki4Takanori Nishiyama5Yoshihiko Hiraga6Masafumi Ueno7Narihisa Suzuki8Seiichi Shinden9Kaoru Ogawa10Hiroyuki Ozawa11Department of Otolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otolaryngology, Head and Neck Surgery, Tokai University School of MedicineDepartment of Otolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otolaryngology, National Hospital Organization Tokyo Medical CenterDepartment of Otolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otolaryngology, Japanese Red Cross Shizuoka HospitalDepartment of Otolaryngology, Saiseikai Utsunomiya HospitalDepartment of Otolaryngology, Hiratsuka City HospitalDepartment of Otolaryngology, Saiseikai Utsunomiya HospitalDepartment of Otolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otolaryngology, Head and Neck Surgery, Keio University School of MedicineAbstract Atherosclerosis is reported to be a risk factor for the severity of idiopathic sudden sensorineural hearing loss (ISSNHL). We evaluated the hypothesis that atherosclerosis affects the hearing thresholds of both the affected and healthy sides of ISSNHL patients. We conducted multivariate analyses on retrospectively collected data of patients with ISSNHL (N = 762) to evaluate the relationship between known factors linked to atherosclerosis and hearing thresholds on affected and healthy sides and whether these factors are prognostic for hearing recovery. Older ages, vertigo or dizziness, diabetes mellitus, and congestive heart failure were significantly related to higher hearing thresholds on the affected side. Older ages, male, and vascular disease were significantly related to higher hearing thresholds on the healthy side. Vertigo or dizziness, severe hearing loss and hearing loss at high frequencies on the affected side, higher hearing thresholds on the healthy side, regular anticoagulant medication, and delayed steroid treatment were significantly related to lack of recovery. Since several atherosclerosis-related factors are associated with higher hearing thresholds on both affected and healthy sides in ISSNHL and higher hearing thresholds on the healthy side predict poorer prognosis, diagnosis, and predicting prognosis of ISSNHL may benefit from rigorous evaluation of patients’ cardiovascular comorbidities and hearing levels on both the healthy and affected sides.https://doi.org/10.1038/s41598-022-25593-5 |
| spellingShingle | Nobuyoshi Tsuzuki Koichiro Wasano Naoki Oishi Ko Hentona Marie Shimanuki Takanori Nishiyama Yoshihiko Hiraga Masafumi Ueno Narihisa Suzuki Seiichi Shinden Kaoru Ogawa Hiroyuki Ozawa Association between atherosclerosis, hearing recovery, and hearing in the healthy ear in idiopathic sudden sensorineural hearing loss: a retrospective chart analysis Scientific Reports |
| title | Association between atherosclerosis, hearing recovery, and hearing in the healthy ear in idiopathic sudden sensorineural hearing loss: a retrospective chart analysis |
| title_full | Association between atherosclerosis, hearing recovery, and hearing in the healthy ear in idiopathic sudden sensorineural hearing loss: a retrospective chart analysis |
| title_fullStr | Association between atherosclerosis, hearing recovery, and hearing in the healthy ear in idiopathic sudden sensorineural hearing loss: a retrospective chart analysis |
| title_full_unstemmed | Association between atherosclerosis, hearing recovery, and hearing in the healthy ear in idiopathic sudden sensorineural hearing loss: a retrospective chart analysis |
| title_short | Association between atherosclerosis, hearing recovery, and hearing in the healthy ear in idiopathic sudden sensorineural hearing loss: a retrospective chart analysis |
| title_sort | association between atherosclerosis hearing recovery and hearing in the healthy ear in idiopathic sudden sensorineural hearing loss a retrospective chart analysis |
| url | https://doi.org/10.1038/s41598-022-25593-5 |
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