Turmeric Herb Extract-Incorporated Biopolymer Dressings with Beneficial Antibacterial, Antioxidant and Anti-Inflammatory Properties for Wound Healing
Bacterial infection and inflammation caused by excess oxidative stress are serious challenges in chronic wound healing. The aim of this work is to investigate a wound dressing based on natural- and biowaste-derived biopolymers loaded with an herb extract that demonstrates antibacterial, antioxidant,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/5/1090 |
| _version_ | 1797614511878832128 |
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| author | Piyachat Chuysinuan Chalinan Pengsuk Kriengsak Lirdprapamongkol Thanyaluck Thanyacharoen Supanna Techasakul Jisnuson Svasti Patcharakamon Nooeaid |
| author_facet | Piyachat Chuysinuan Chalinan Pengsuk Kriengsak Lirdprapamongkol Thanyaluck Thanyacharoen Supanna Techasakul Jisnuson Svasti Patcharakamon Nooeaid |
| author_sort | Piyachat Chuysinuan |
| collection | DOAJ |
| description | Bacterial infection and inflammation caused by excess oxidative stress are serious challenges in chronic wound healing. The aim of this work is to investigate a wound dressing based on natural- and biowaste-derived biopolymers loaded with an herb extract that demonstrates antibacterial, antioxidant, and anti-inflammatory activities without using additional synthetic drugs. Turmeric extract-loaded carboxymethyl cellulose/silk sericin dressings were produced by esterification crosslinking with citric acid followed by freeze-drying to achieve an interconnected porous structure, sufficient mechanical properties, and hydrogel formation in situ in contact with an aqueous solution. The dressings exhibited inhibitory effects on the growth of bacterial strains that were related to the controlled release of the turmeric extract. The dressings provided antioxidant activity as a result of the radical scavenging effect on DPPH, ABTS, and FRAP radicals. To confirm their anti-inflammatory effects, the inhibition of nitric oxide production in activated RAW 264.7 macrophages was investigated. The findings suggested that the dressings could be a potential candidate for wound healing. |
| first_indexed | 2024-03-11T07:13:32Z |
| format | Article |
| id | doaj.art-4fbb79d816594eedb884aa4a86c53ac0 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T07:13:32Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-4fbb79d816594eedb884aa4a86c53ac02023-11-17T08:25:59ZengMDPI AGPolymers2073-43602023-02-01155109010.3390/polym15051090Turmeric Herb Extract-Incorporated Biopolymer Dressings with Beneficial Antibacterial, Antioxidant and Anti-Inflammatory Properties for Wound HealingPiyachat Chuysinuan0Chalinan Pengsuk1Kriengsak Lirdprapamongkol2Thanyaluck Thanyacharoen3Supanna Techasakul4Jisnuson Svasti5Patcharakamon Nooeaid6Laboratory of Organic Synthesis, Chulabhorn Research Institute, Bangkok 10210, ThailandDivision of Biotechnology Technology and Agricultural Products, Faculty of Agricultural Product Innovation and Technology, Srinakharinwirot University, Ongkarak, Nakhon Nayok 26120, ThailandLaboratory of Biochemistry, Chulabhorn Research Institute, Bangkok 10210, ThailandLaboratory of Organic Synthesis, Chulabhorn Research Institute, Bangkok 10210, ThailandLaboratory of Organic Synthesis, Chulabhorn Research Institute, Bangkok 10210, ThailandLaboratory of Biochemistry, Chulabhorn Research Institute, Bangkok 10210, ThailandDivision of Polymer Materials Technology, Faculty of Agricultural Product Innovation and Technology, Srinakharinwirot University, Ongkarak, Nakhon Nayok 26120, ThailandBacterial infection and inflammation caused by excess oxidative stress are serious challenges in chronic wound healing. The aim of this work is to investigate a wound dressing based on natural- and biowaste-derived biopolymers loaded with an herb extract that demonstrates antibacterial, antioxidant, and anti-inflammatory activities without using additional synthetic drugs. Turmeric extract-loaded carboxymethyl cellulose/silk sericin dressings were produced by esterification crosslinking with citric acid followed by freeze-drying to achieve an interconnected porous structure, sufficient mechanical properties, and hydrogel formation in situ in contact with an aqueous solution. The dressings exhibited inhibitory effects on the growth of bacterial strains that were related to the controlled release of the turmeric extract. The dressings provided antioxidant activity as a result of the radical scavenging effect on DPPH, ABTS, and FRAP radicals. To confirm their anti-inflammatory effects, the inhibition of nitric oxide production in activated RAW 264.7 macrophages was investigated. The findings suggested that the dressings could be a potential candidate for wound healing.https://www.mdpi.com/2073-4360/15/5/1090wound dressingantibacterial propertyantioxidant activityanti-inflammatory propertybiopolymersturmeric extract |
| spellingShingle | Piyachat Chuysinuan Chalinan Pengsuk Kriengsak Lirdprapamongkol Thanyaluck Thanyacharoen Supanna Techasakul Jisnuson Svasti Patcharakamon Nooeaid Turmeric Herb Extract-Incorporated Biopolymer Dressings with Beneficial Antibacterial, Antioxidant and Anti-Inflammatory Properties for Wound Healing Polymers wound dressing antibacterial property antioxidant activity anti-inflammatory property biopolymers turmeric extract |
| title | Turmeric Herb Extract-Incorporated Biopolymer Dressings with Beneficial Antibacterial, Antioxidant and Anti-Inflammatory Properties for Wound Healing |
| title_full | Turmeric Herb Extract-Incorporated Biopolymer Dressings with Beneficial Antibacterial, Antioxidant and Anti-Inflammatory Properties for Wound Healing |
| title_fullStr | Turmeric Herb Extract-Incorporated Biopolymer Dressings with Beneficial Antibacterial, Antioxidant and Anti-Inflammatory Properties for Wound Healing |
| title_full_unstemmed | Turmeric Herb Extract-Incorporated Biopolymer Dressings with Beneficial Antibacterial, Antioxidant and Anti-Inflammatory Properties for Wound Healing |
| title_short | Turmeric Herb Extract-Incorporated Biopolymer Dressings with Beneficial Antibacterial, Antioxidant and Anti-Inflammatory Properties for Wound Healing |
| title_sort | turmeric herb extract incorporated biopolymer dressings with beneficial antibacterial antioxidant and anti inflammatory properties for wound healing |
| topic | wound dressing antibacterial property antioxidant activity anti-inflammatory property biopolymers turmeric extract |
| url | https://www.mdpi.com/2073-4360/15/5/1090 |
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