Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis
(1) Objective: We aimed to evaluate the effect of treatment with prednisone on nasal and systemic periostin and eotaxin expression, IgE in plasma and eosinophils in tissue. (2) Methods: We compared the values of nasal and systemic periostin, eotaxin, IgE and eosinophils in tissue in patients treated...
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MDPI AG
2023-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/7/1354 |
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| author | Malgorzata Wierzchowska Paulina Kalińczak-Górna Magdalena Zwolińska Joanna Ligmanowska Justyna Durślewicz Aleksander Zwierz Bartosz Malinowski Michał Wiciński Paweł Burduk |
| author_facet | Malgorzata Wierzchowska Paulina Kalińczak-Górna Magdalena Zwolińska Joanna Ligmanowska Justyna Durślewicz Aleksander Zwierz Bartosz Malinowski Michał Wiciński Paweł Burduk |
| author_sort | Malgorzata Wierzchowska |
| collection | DOAJ |
| description | (1) Objective: We aimed to evaluate the effect of treatment with prednisone on nasal and systemic periostin and eotaxin expression, IgE in plasma and eosinophils in tissue. (2) Methods: We compared the values of nasal and systemic periostin, eotaxin, IgE and eosinophils in tissue in patients treated with only nasal steroids before FESS, group 1, with those treated with an oral steroid–prednisone, group 2. (3) Results: A statistically significant decrease in the level of periostin, eotaxin and IgE in plasma was achieved in patients treated with prednisone one week before and after surgery (in sequence: <i>p</i> < 0.0476, <i>p</i> < 0.0006, <i>p</i> < 0.0031). In patients treated with steroids, we also observed a lower level of periostin in the epithelium (<i>p</i> < 0.044), eotaxin in the stroma (<i>p</i> limit value < 0.075) and eosinophils (<i>p</i> < 0.031) in the tissues collected during the operation. (4) Conclusions: Systemic steroid treatment with prednisone distinctly decreases periostin, eotaxin and IgE expression in plasma. We also observed a lower level of periostin in the epithelium, eotaxin in the stroma and eosinophils in the tissues. We need more attempts to find inflammatory markers associated with chronic rhinosinusitis. Identifying drugs that decrease inflammatory parameters would allow for more targeted therapy. |
| first_indexed | 2024-03-11T05:39:44Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T05:39:44Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-4fbe5e4d9607452f8b2ee1bca49984762023-11-17T16:31:27ZengMDPI AGDiagnostics2075-44182023-04-01137135410.3390/diagnostics13071354Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic RhinosinusitisMalgorzata Wierzchowska0Paulina Kalińczak-Górna1Magdalena Zwolińska2Joanna Ligmanowska3Justyna Durślewicz4Aleksander Zwierz5Bartosz Malinowski6Michał Wiciński7Paweł Burduk8Department of Otolaryngology, Phoniatrics and Audiology, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, PolandDepartment of Otolaryngology, The Provincial Polyclinical Hospital in Toruń, 87-100 Toruń, PolandDepartment of Clinical Pathomorphology, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, PolandDepartment of Pathophysiology, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, PolandDepartment of Clinical Pathomorphology, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, PolandDepartment of Otolaryngology, Phoniatrics and Audiology, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, PolandDepartment of Pharmacology and Therapy, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, PolandDepartment of Pharmacology and Therapy, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, PolandDepartment of Otolaryngology, Phoniatrics and Audiology, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, Poland(1) Objective: We aimed to evaluate the effect of treatment with prednisone on nasal and systemic periostin and eotaxin expression, IgE in plasma and eosinophils in tissue. (2) Methods: We compared the values of nasal and systemic periostin, eotaxin, IgE and eosinophils in tissue in patients treated with only nasal steroids before FESS, group 1, with those treated with an oral steroid–prednisone, group 2. (3) Results: A statistically significant decrease in the level of periostin, eotaxin and IgE in plasma was achieved in patients treated with prednisone one week before and after surgery (in sequence: <i>p</i> < 0.0476, <i>p</i> < 0.0006, <i>p</i> < 0.0031). In patients treated with steroids, we also observed a lower level of periostin in the epithelium (<i>p</i> < 0.044), eotaxin in the stroma (<i>p</i> limit value < 0.075) and eosinophils (<i>p</i> < 0.031) in the tissues collected during the operation. (4) Conclusions: Systemic steroid treatment with prednisone distinctly decreases periostin, eotaxin and IgE expression in plasma. We also observed a lower level of periostin in the epithelium, eotaxin in the stroma and eosinophils in the tissues. We need more attempts to find inflammatory markers associated with chronic rhinosinusitis. Identifying drugs that decrease inflammatory parameters would allow for more targeted therapy.https://www.mdpi.com/2075-4418/13/7/1354rhinosinusitisinflammationFESSprednisonesteroid |
| spellingShingle | Malgorzata Wierzchowska Paulina Kalińczak-Górna Magdalena Zwolińska Joanna Ligmanowska Justyna Durślewicz Aleksander Zwierz Bartosz Malinowski Michał Wiciński Paweł Burduk Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis Diagnostics rhinosinusitis inflammation FESS prednisone steroid |
| title | Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis |
| title_full | Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis |
| title_fullStr | Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis |
| title_full_unstemmed | Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis |
| title_short | Effect of Systemic Prednisone Treatment on Changes of Inflammation Markers in Chronic Rhinosinusitis |
| title_sort | effect of systemic prednisone treatment on changes of inflammation markers in chronic rhinosinusitis |
| topic | rhinosinusitis inflammation FESS prednisone steroid |
| url | https://www.mdpi.com/2075-4418/13/7/1354 |
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