Rapid stromal remodeling by short‐term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma

Rapid stromal remodeling by short‐term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma

Anti‐angiogenic agents combined with chemotherapy is an important strategy for the treatment of solid tumors. However, survival benefit is limited, urging the improvement of combination therapies. We aimed to clarify the effects of vascular endothelial growth factor receptor 2 (VEGFR2) targeting on...

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Bibliographic Details
Main Authors: Anne Steins, Remy Klaassen, Igor Jacobs, Matthias C. Schabel, Monique G. J. T. B. vanLier, Eva A. Ebbing, Stefanie J. Hectors, Sander W. Tas, Chrissta X. Maracle, Cornelis J. A. Punt, Maria Siebes, Jacques J. G. H. M. Bergman, Jan Paul Medema, Johanna W. Wilmink, Ron A. A. Mathot, Gustav J. Strijkers, Maarten F. Bijlsma, Hanneke W. M. vanLaarhoven
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Molecular Oncology
Subjects:
anti‐angiogenic therapy
chemotherapy
DCE‐MRI
esophagogastric adenocarcinoma
stromal remodeling
Online Access:https://doi.org/10.1002/1878-0261.12599

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