A photoacoustics-enhanced drilling probe for radiation-free pedicle screw implantation in spinal surgery
This article proposes a novel intra-operative navigation and sensing system that optimizes the functional accuracy of spinal pedicle screw implantation. It does so by incorporating radiation-free and multi-scale macroscopic 3D ultrasound (US) imaging and local tissue-awareness from in situ photoacou...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1000950/full |
| _version_ | 1797995292360966144 |
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| author | Li Liu Yongjian Zhao Ang Li Xianghu Yu Xiao Xiao Siyu Liu Max Q.-H. Meng Max Q.-H. Meng |
| author_facet | Li Liu Yongjian Zhao Ang Li Xianghu Yu Xiao Xiao Siyu Liu Max Q.-H. Meng Max Q.-H. Meng |
| author_sort | Li Liu |
| collection | DOAJ |
| description | This article proposes a novel intra-operative navigation and sensing system that optimizes the functional accuracy of spinal pedicle screw implantation. It does so by incorporating radiation-free and multi-scale macroscopic 3D ultrasound (US) imaging and local tissue-awareness from in situ photoacoustic (PA) sensing at a clinically relevant mesoscopic scale. More specifically, 3D US imaging is employed for online status updates of spinal segment posture to determine the appropriate entry point and coarse drilling path once non-negligible or relative patient motion occurs between inter-vertebral segments in the intra-operative phase. Furthermore, a sophisticated sensor-enhanced drilling probe has been developed to facilitate fine-grained local navigation that integrates a PA endoscopic imaging component for in situ tissue sensing. The PA signals from a sideways direction to differentiate cancellous bone from harder cortical bone, or to indicate weakened osteoporotic bone within the vertebrae. In so doing it prevents cortical breaches, strengthens implant stability, and mitigates iatrogenic injuries of the neighboring artery and nerves. To optimize this PA-enhanced endoscopic probe design, the light absorption spectrum of cortical bone and cancellous bone are measured in vitro, and the associated PA signals are characterized. Ultimately, a pilot study is performed on an ex vivo bovine spine to validate our developed multi-scale navigation and sensing system. The experimental results demonstrate the clinical feasibility, and hence the great potential, for functionally accurate screw implantation in complex spinal stabilization interventions. |
| first_indexed | 2024-04-11T09:59:25Z |
| format | Article |
| id | doaj.art-4fc05e3ba5bc46668fae6ef200e0e91b |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T09:59:25Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-4fc05e3ba5bc46668fae6ef200e0e91b2022-12-22T04:30:28ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.10009501000950A photoacoustics-enhanced drilling probe for radiation-free pedicle screw implantation in spinal surgeryLi Liu0Yongjian Zhao1Ang Li2Xianghu Yu3Xiao Xiao4Siyu Liu5Max Q.-H. Meng6Max Q.-H. Meng7Department of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen, ChinaSchool of Science, Nanjing University of Science and Technology, Nanjing, ChinaDepartment of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen, ChinaThis article proposes a novel intra-operative navigation and sensing system that optimizes the functional accuracy of spinal pedicle screw implantation. It does so by incorporating radiation-free and multi-scale macroscopic 3D ultrasound (US) imaging and local tissue-awareness from in situ photoacoustic (PA) sensing at a clinically relevant mesoscopic scale. More specifically, 3D US imaging is employed for online status updates of spinal segment posture to determine the appropriate entry point and coarse drilling path once non-negligible or relative patient motion occurs between inter-vertebral segments in the intra-operative phase. Furthermore, a sophisticated sensor-enhanced drilling probe has been developed to facilitate fine-grained local navigation that integrates a PA endoscopic imaging component for in situ tissue sensing. The PA signals from a sideways direction to differentiate cancellous bone from harder cortical bone, or to indicate weakened osteoporotic bone within the vertebrae. In so doing it prevents cortical breaches, strengthens implant stability, and mitigates iatrogenic injuries of the neighboring artery and nerves. To optimize this PA-enhanced endoscopic probe design, the light absorption spectrum of cortical bone and cancellous bone are measured in vitro, and the associated PA signals are characterized. Ultimately, a pilot study is performed on an ex vivo bovine spine to validate our developed multi-scale navigation and sensing system. The experimental results demonstrate the clinical feasibility, and hence the great potential, for functionally accurate screw implantation in complex spinal stabilization interventions.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1000950/fullmulti-scale navigation and sensingultrasound-based surgical navigationphotoacoustic endoscopyrobotic-assisted spinal surgerycancellous bone characterizationin situ tissue sensing |
| spellingShingle | Li Liu Yongjian Zhao Ang Li Xianghu Yu Xiao Xiao Siyu Liu Max Q.-H. Meng Max Q.-H. Meng A photoacoustics-enhanced drilling probe for radiation-free pedicle screw implantation in spinal surgery Frontiers in Bioengineering and Biotechnology multi-scale navigation and sensing ultrasound-based surgical navigation photoacoustic endoscopy robotic-assisted spinal surgery cancellous bone characterization in situ tissue sensing |
| title | A photoacoustics-enhanced drilling probe for radiation-free pedicle screw implantation in spinal surgery |
| title_full | A photoacoustics-enhanced drilling probe for radiation-free pedicle screw implantation in spinal surgery |
| title_fullStr | A photoacoustics-enhanced drilling probe for radiation-free pedicle screw implantation in spinal surgery |
| title_full_unstemmed | A photoacoustics-enhanced drilling probe for radiation-free pedicle screw implantation in spinal surgery |
| title_short | A photoacoustics-enhanced drilling probe for radiation-free pedicle screw implantation in spinal surgery |
| title_sort | photoacoustics enhanced drilling probe for radiation free pedicle screw implantation in spinal surgery |
| topic | multi-scale navigation and sensing ultrasound-based surgical navigation photoacoustic endoscopy robotic-assisted spinal surgery cancellous bone characterization in situ tissue sensing |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1000950/full |
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