The associations between renal disease severity and exposure to organophosphate flame retardants in patients with chronic kidney disease
Organophosphate flame retardants (OPFRs) are emerging and widespread environmental pollutants with potential health hazards, including nephrotoxicity. However, the exposure patterns and nephrotoxic potential of OPFRs are yet to be investigated in patients with chronic kidney disease (CKD). We conduc...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022005001 |
| _version_ | 1811185529513836544 |
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| author | Kai-Fan Tsai Fu-Jen Cheng Wan-Ting Huang Chia-Te Kung Chien-Te Lee Ben-Chung Cheng Jin-Bor Chen Shau-Hsuan Li Chin-Chou Wang Liang-Jen Wang Yu-Che Ou Wen-Chin Lee |
| author_facet | Kai-Fan Tsai Fu-Jen Cheng Wan-Ting Huang Chia-Te Kung Chien-Te Lee Ben-Chung Cheng Jin-Bor Chen Shau-Hsuan Li Chin-Chou Wang Liang-Jen Wang Yu-Che Ou Wen-Chin Lee |
| author_sort | Kai-Fan Tsai |
| collection | DOAJ |
| description | Organophosphate flame retardants (OPFRs) are emerging and widespread environmental pollutants with potential health hazards, including nephrotoxicity. However, the exposure patterns and nephrotoxic potential of OPFRs are yet to be investigated in patients with chronic kidney disease (CKD). We conducted a cross-sectional study involving 166 patients with CKD stratified by estimated glomerular filtration rate (eGFR) and severity of proteinuria. The urinary concentrations of 10 OPFR compounds were measured to evaluate the exposure patterns. Clinical and urinary OPFR profiles were compared among subgroups to identify whether the OPFR compounds were independently correlated with eGFR and proteinuria. Additionally, lifestyle factors were compared among subgroups stratified by median concentrations of urinary OPFR compounds associated with renal disease severity. This study revealed universal exposure to OPFRs in the CKD population, with an overall urinary detection rate of 98.80 %. Furthermore, after adjusting for covariates, the urinary concentration of bis(2-chloroethyl) phosphate (BCEP) was identified as an independent predictor of lower eGFR (low vs high eGFR, odds ratio (OR) (95 % confidence interval (CI)), 1.761 (1.032–3.005) per log μg/g creatinine, p = 0.038), and the urinary concentration of bis(2-butoxyethyl) phosphate (BBOEP) was independently correlated with overt proteinuria in CKD patients (with vs without overt proteinuria, OR (95 % CI), 1.813 (1.065–3.086) per log μg/g creatinine, p = 0.028). Moreover, frequent seafood consumption was negatively correlated with urinary BCEP concentration (high vs low BCEP, OR (95 % CI), 0.455 (0.228–0.908), p = 0.025), and age was inversely associated with urinary BBOEP concentration (high vs low BBOEP, OR (95 % CI), 0.968 (0.937–0.999) per year, p = 0.048). In conclusion, our investigation highlights the extensive exposure to OPFRs and the independent association between renal disease severity and urinary BCEP/BBOEP concentrations in the CKD population, indicating the nephrotoxic potential of these pollutants. |
| first_indexed | 2024-04-11T13:30:58Z |
| format | Article |
| id | doaj.art-4fc068e9c80249a0951057cb25bc5e10 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-11T13:30:58Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-4fc068e9c80249a0951057cb25bc5e102022-12-22T04:21:49ZengElsevierEnvironment International0160-41202022-12-01170107573The associations between renal disease severity and exposure to organophosphate flame retardants in patients with chronic kidney diseaseKai-Fan Tsai0Fu-Jen Cheng1Wan-Ting Huang2Chia-Te Kung3Chien-Te Lee4Ben-Chung Cheng5Jin-Bor Chen6Shau-Hsuan Li7Chin-Chou Wang8Liang-Jen Wang9Yu-Che Ou10Wen-Chin Lee11Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan, R.O.C.Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Occupational Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Corresponding author at: Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, 123, Dabi Rd., Kaohsiung 83301, Taiwan.Organophosphate flame retardants (OPFRs) are emerging and widespread environmental pollutants with potential health hazards, including nephrotoxicity. However, the exposure patterns and nephrotoxic potential of OPFRs are yet to be investigated in patients with chronic kidney disease (CKD). We conducted a cross-sectional study involving 166 patients with CKD stratified by estimated glomerular filtration rate (eGFR) and severity of proteinuria. The urinary concentrations of 10 OPFR compounds were measured to evaluate the exposure patterns. Clinical and urinary OPFR profiles were compared among subgroups to identify whether the OPFR compounds were independently correlated with eGFR and proteinuria. Additionally, lifestyle factors were compared among subgroups stratified by median concentrations of urinary OPFR compounds associated with renal disease severity. This study revealed universal exposure to OPFRs in the CKD population, with an overall urinary detection rate of 98.80 %. Furthermore, after adjusting for covariates, the urinary concentration of bis(2-chloroethyl) phosphate (BCEP) was identified as an independent predictor of lower eGFR (low vs high eGFR, odds ratio (OR) (95 % confidence interval (CI)), 1.761 (1.032–3.005) per log μg/g creatinine, p = 0.038), and the urinary concentration of bis(2-butoxyethyl) phosphate (BBOEP) was independently correlated with overt proteinuria in CKD patients (with vs without overt proteinuria, OR (95 % CI), 1.813 (1.065–3.086) per log μg/g creatinine, p = 0.028). Moreover, frequent seafood consumption was negatively correlated with urinary BCEP concentration (high vs low BCEP, OR (95 % CI), 0.455 (0.228–0.908), p = 0.025), and age was inversely associated with urinary BBOEP concentration (high vs low BBOEP, OR (95 % CI), 0.968 (0.937–0.999) per year, p = 0.048). In conclusion, our investigation highlights the extensive exposure to OPFRs and the independent association between renal disease severity and urinary BCEP/BBOEP concentrations in the CKD population, indicating the nephrotoxic potential of these pollutants.http://www.sciencedirect.com/science/article/pii/S0160412022005001Bis(2-butoxyethyl) phosphateChronic kidney diseaseEstimated glomerular filtration rateOrganophosphate flame retardantProteinuriaBis(2-chloroethyl) phosphate |
| spellingShingle | Kai-Fan Tsai Fu-Jen Cheng Wan-Ting Huang Chia-Te Kung Chien-Te Lee Ben-Chung Cheng Jin-Bor Chen Shau-Hsuan Li Chin-Chou Wang Liang-Jen Wang Yu-Che Ou Wen-Chin Lee The associations between renal disease severity and exposure to organophosphate flame retardants in patients with chronic kidney disease Environment International Bis(2-butoxyethyl) phosphate Chronic kidney disease Estimated glomerular filtration rate Organophosphate flame retardant Proteinuria Bis(2-chloroethyl) phosphate |
| title | The associations between renal disease severity and exposure to organophosphate flame retardants in patients with chronic kidney disease |
| title_full | The associations between renal disease severity and exposure to organophosphate flame retardants in patients with chronic kidney disease |
| title_fullStr | The associations between renal disease severity and exposure to organophosphate flame retardants in patients with chronic kidney disease |
| title_full_unstemmed | The associations between renal disease severity and exposure to organophosphate flame retardants in patients with chronic kidney disease |
| title_short | The associations between renal disease severity and exposure to organophosphate flame retardants in patients with chronic kidney disease |
| title_sort | associations between renal disease severity and exposure to organophosphate flame retardants in patients with chronic kidney disease |
| topic | Bis(2-butoxyethyl) phosphate Chronic kidney disease Estimated glomerular filtration rate Organophosphate flame retardant Proteinuria Bis(2-chloroethyl) phosphate |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022005001 |
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