High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections
Central nervous system (CNS) infections such as encephalitis, meningitis, or myelitis have high morbidity and mortality in Indonesia. High sensitivity C-reactive protein (hs-CRP) is a sensitive marker of acute inflammation, while albumin is the most abundant protein component in plasma and cerebrosp...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2023-12-01
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| Series: | Journal of the Medical Sciences |
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| Online Access: | https://jurnal.ugm.ac.id/bik/article/view/82453 |
| _version_ | 1797355347831160832 |
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| author | Hanifah Fajarisna Hayati Sekar Satiti Paryono Paryono Umi Intansari Sri Sutarni Subagya Subagya Indarwati Indarwati Ismail Setyopranoto |
| author_facet | Hanifah Fajarisna Hayati Sekar Satiti Paryono Paryono Umi Intansari Sri Sutarni Subagya Subagya Indarwati Indarwati Ismail Setyopranoto |
| author_sort | Hanifah Fajarisna Hayati |
| collection | DOAJ |
| description | Central nervous system (CNS) infections such as encephalitis, meningitis, or myelitis have high morbidity and mortality in Indonesia. High sensitivity C-reactive protein (hs-CRP) is a sensitive marker of acute inflammation, while albumin is the most abundant protein component in plasma and cerebrospinal fluid (CSS). Infection triggers an inflammatory response so that an increase in the hs-CRP/albumin ratio (CAR) can be a predictor of worsening clinical outcome in patients with CNS infections. However, studies examining the predictor value of serum and CSF CAR on worsening clinical outcomes of patients are limited, particularly in CNS infections. The purpose of this study was to prove the CAR as a predictor of worsening clinical outcome in patients with CNS infections. It was an observational study using a prospective cohort design. Fifty subjects recruited until October 2021 at Dr. Sardjito General Hospital were involved. The multivariate regression analysis showed that serum CAR (OR=3.604; 95%CI=1.487-8.736; p =0.005) could be a single predictor. However, by combining three variables, namely serum CAR, CSF CAR, and decreased consciousness at admission, could be a stronger predictor of worsening clinical outcome in patients with CNS infection (AUC = 97.1%; 95%CI = 0.929-1.00; p <0.001). The optimal cut-off value for serum CAR was 1.35 (Youden index = 0.88, sensitivity = 96%, specificity = 92%) while for CSF CAR was 0.14 (Youden index = 0.60, sensitivity = 76%, specificity = 84%). In conclusion, a combination predictive model of three variables, namely serum CAR, CSF CAR, and awareness at admission can be a stronger predictor of clinical outcome in patients with CNS infection than serum CAR alone. |
| first_indexed | 2024-03-08T14:09:49Z |
| format | Article |
| id | doaj.art-4fc1f7fa5fd047b58dd81ac95b8b6878 |
| institution | Directory Open Access Journal |
| issn | 2356-3931 |
| language | English |
| last_indexed | 2024-03-08T14:09:49Z |
| publishDate | 2023-12-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Journal of the Medical Sciences |
| spelling | doaj.art-4fc1f7fa5fd047b58dd81ac95b8b68782024-01-15T00:55:58ZengUniversitas Gadjah MadaJournal of the Medical Sciences2356-39312023-12-0155434986High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infectionsHanifah Fajarisna Hayati0Sekar Satiti1Paryono Paryono2Umi Intansari3Sri Sutarni4Subagya Subagya5Indarwati Indarwati6Ismail Setyopranoto7Neurology Resident, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/ Dr. Sardjito General Hospital, YogyakartaDepartment of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, YogyakartaDepartment of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, YogyakartaDepartment of Clinical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, YogyakartaDepartment of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, YogyakartaDepartment of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, YogyakartaDepartment of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, YogyakartaDepartment of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, YogyakartaCentral nervous system (CNS) infections such as encephalitis, meningitis, or myelitis have high morbidity and mortality in Indonesia. High sensitivity C-reactive protein (hs-CRP) is a sensitive marker of acute inflammation, while albumin is the most abundant protein component in plasma and cerebrospinal fluid (CSS). Infection triggers an inflammatory response so that an increase in the hs-CRP/albumin ratio (CAR) can be a predictor of worsening clinical outcome in patients with CNS infections. However, studies examining the predictor value of serum and CSF CAR on worsening clinical outcomes of patients are limited, particularly in CNS infections. The purpose of this study was to prove the CAR as a predictor of worsening clinical outcome in patients with CNS infections. It was an observational study using a prospective cohort design. Fifty subjects recruited until October 2021 at Dr. Sardjito General Hospital were involved. The multivariate regression analysis showed that serum CAR (OR=3.604; 95%CI=1.487-8.736; p =0.005) could be a single predictor. However, by combining three variables, namely serum CAR, CSF CAR, and decreased consciousness at admission, could be a stronger predictor of worsening clinical outcome in patients with CNS infection (AUC = 97.1%; 95%CI = 0.929-1.00; p <0.001). The optimal cut-off value for serum CAR was 1.35 (Youden index = 0.88, sensitivity = 96%, specificity = 92%) while for CSF CAR was 0.14 (Youden index = 0.60, sensitivity = 76%, specificity = 84%). In conclusion, a combination predictive model of three variables, namely serum CAR, CSF CAR, and awareness at admission can be a stronger predictor of clinical outcome in patients with CNS infection than serum CAR alone.https://jurnal.ugm.ac.id/bik/article/view/82453central nervous system infectionbarthel indexcsf hs-crp/albumin ratioserum hs-crp/albumin ratiocut-off value |
| spellingShingle | Hanifah Fajarisna Hayati Sekar Satiti Paryono Paryono Umi Intansari Sri Sutarni Subagya Subagya Indarwati Indarwati Ismail Setyopranoto High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections Journal of the Medical Sciences central nervous system infection barthel index csf hs-crp/albumin ratio serum hs-crp/albumin ratio cut-off value |
| title | High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections |
| title_full | High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections |
| title_fullStr | High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections |
| title_full_unstemmed | High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections |
| title_short | High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections |
| title_sort | high sensitivity c reactive protein albumin hs crp albumin ratio as a predictor of deterioration of clinical outcome in central nervous system infections |
| topic | central nervous system infection barthel index csf hs-crp/albumin ratio serum hs-crp/albumin ratio cut-off value |
| url | https://jurnal.ugm.ac.id/bik/article/view/82453 |
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