Role of glutamic acid residues 154, 155, and 165 of lecithin:cholesterol acyltransferase in cholesterol esterification and phospholipase A2 activities

Role of glutamic acid residues 154, 155, and 165 of lecithin:cholesterol acyltransferase in cholesterol esterification and phospholipase A2 activities

Previous studies have shown that cholesterol esterification activity by lecithin:cholesterol acyltransferase (LCAT) is progressively inhibited as up to three acidic acid residues are chemically modified. The purpose of this study was to determine whether three glutamic acid residues in LCAT (154, 15...

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Bibliographic Details
Main Authors: Jingchuan Wang, Jeanine A. DeLozier, Abraham K. Gebre, Peter J. Dolphin, John S. Parks
Format: Article
Language:English
Published: Elsevier 1998-01-01
Series:Journal of Lipid Research
Subjects:
COS cells
apolipoprotein E
apolipoprotein A-I
recombinant HDL mutagenesis
glutamic acid
LCAT
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520342024

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http://www.sciencedirect.com/science/article/pii/S0022227520342024

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