Diagnostic biomarkers for active tuberculosis: progress and challenges
Abstract Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious agent, despite being preventable and curable. Early and accurate diagnosis of active TB is critical to both enhance patient care, improve patient outcomes, and break Mycobacterium tuberculosis (Mtb) tra...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2022-10-01
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| Series: | EMBO Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.15252/emmm.202114088 |
| _version_ | 1827045115541061632 |
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| author | Betânia M F Nogueira Sonya Krishnan Beatriz Barreto‐Duarte Mariana Araújo‐Pereira Artur T L Queiroz Jerrold J Ellner Padmini Salgame Thomas J Scriba Timothy R Sterling Amita Gupta Bruno B Andrade |
| author_facet | Betânia M F Nogueira Sonya Krishnan Beatriz Barreto‐Duarte Mariana Araújo‐Pereira Artur T L Queiroz Jerrold J Ellner Padmini Salgame Thomas J Scriba Timothy R Sterling Amita Gupta Bruno B Andrade |
| author_sort | Betânia M F Nogueira |
| collection | DOAJ |
| description | Abstract Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious agent, despite being preventable and curable. Early and accurate diagnosis of active TB is critical to both enhance patient care, improve patient outcomes, and break Mycobacterium tuberculosis (Mtb) transmission cycles. In 2020 an estimated 9.9 million people fell ill from Mtb, but only a little over half (5.8 million) received an active TB diagnosis and treatment. The World Health Organization has proposed target product profiles for biomarker‐ or biosignature‐based diagnostics using point‐of‐care tests from easily accessible specimens such as urine or blood. Here we review and summarize progress made in the development of pathogen‐ and host‐based biomarkers for active TB diagnosis. We describe several unique patient populations that have posed challenges to development of a universal diagnostic TB biomarker, such as people living with HIV, extrapulmonary TB, and children. We also review additional limitations to widespread validation and utilization of published biomarkers. We conclude with proposed solutions to enhance TB diagnostic biomarker validation and uptake. |
| first_indexed | 2024-03-07T17:41:53Z |
| format | Article |
| id | doaj.art-4fc2d5911d0b44a3ba60614366d13b73 |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2025-02-18T14:19:42Z |
| publishDate | 2022-10-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-4fc2d5911d0b44a3ba60614366d13b732024-10-28T08:51:53ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842022-10-01141211310.15252/emmm.202114088Diagnostic biomarkers for active tuberculosis: progress and challengesBetânia M F Nogueira0Sonya Krishnan1Beatriz Barreto‐Duarte2Mariana Araújo‐Pereira3Artur T L Queiroz4Jerrold J Ellner5Padmini Salgame6Thomas J Scriba7Timothy R Sterling8Amita Gupta9Bruno B Andrade10Programa de Pós‐graduação em Ciências da Saúde, Universidade Federal da BahiaDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of MedicineMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) InitiativeMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) InitiativeInstituto Couto MaiaDepartment of Medicine, Centre for Emerging Pathogens, Rutgers‐New Jersey Medical SchoolDepartment of Medicine, Centre for Emerging Pathogens, Rutgers‐New Jersey Medical SchoolSouth African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape TownDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical CenterDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of MedicineMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) InitiativeAbstract Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious agent, despite being preventable and curable. Early and accurate diagnosis of active TB is critical to both enhance patient care, improve patient outcomes, and break Mycobacterium tuberculosis (Mtb) transmission cycles. In 2020 an estimated 9.9 million people fell ill from Mtb, but only a little over half (5.8 million) received an active TB diagnosis and treatment. The World Health Organization has proposed target product profiles for biomarker‐ or biosignature‐based diagnostics using point‐of‐care tests from easily accessible specimens such as urine or blood. Here we review and summarize progress made in the development of pathogen‐ and host‐based biomarkers for active TB diagnosis. We describe several unique patient populations that have posed challenges to development of a universal diagnostic TB biomarker, such as people living with HIV, extrapulmonary TB, and children. We also review additional limitations to widespread validation and utilization of published biomarkers. We conclude with proposed solutions to enhance TB diagnostic biomarker validation and uptake.https://doi.org/10.15252/emmm.202114088active TBbiomarkersdiagnostic biomarkerstuberculosis |
| spellingShingle | Betânia M F Nogueira Sonya Krishnan Beatriz Barreto‐Duarte Mariana Araújo‐Pereira Artur T L Queiroz Jerrold J Ellner Padmini Salgame Thomas J Scriba Timothy R Sterling Amita Gupta Bruno B Andrade Diagnostic biomarkers for active tuberculosis: progress and challenges EMBO Molecular Medicine active TB biomarkers diagnostic biomarkers tuberculosis |
| title | Diagnostic biomarkers for active tuberculosis: progress and challenges |
| title_full | Diagnostic biomarkers for active tuberculosis: progress and challenges |
| title_fullStr | Diagnostic biomarkers for active tuberculosis: progress and challenges |
| title_full_unstemmed | Diagnostic biomarkers for active tuberculosis: progress and challenges |
| title_short | Diagnostic biomarkers for active tuberculosis: progress and challenges |
| title_sort | diagnostic biomarkers for active tuberculosis progress and challenges |
| topic | active TB biomarkers diagnostic biomarkers tuberculosis |
| url | https://doi.org/10.15252/emmm.202114088 |
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