The amelioration of renal damage in Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice.

The amelioration of renal damage in Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice.

SCF-Skp2 E3 ubiquitin ligase (Skp2 hereafter) targets several cell cycle regulatory proteins for degradation via the ubiquitin-dependent pathway. However, the target-specific physiological functions of Skp2 have not been fully elucidated in kidney diseases. We previously reported an increase in Skp2...

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Main Authors: Sayuri Suzuki, Hirotaka Fukasawa, Taro Misaki, Akashi Togawa, Naro Ohashi, Kyoko Kitagawa, Yojiro Kotake, Ning Liu, Hiroyuki Niida, Keiko Nakayama, Keiichi I Nakayama, Tatsuo Yamamoto, Masatoshi Kitagawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338689?pdf=render

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