Hormesis and Epidermal Stem Cells
This paper provides an assessment of hormetic dose responses in epidermal stem cells (EpSCs) in animal models and humans, with emphasis on cell proliferation and differentiation and application to wound healing and aging processes. Hormetic dose responses were induced by several agents, including di...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-09-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/15593258221119911 |
| _version_ | 1798000580449271808 |
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| author | Edward J. Calabrese Vittorio Calabrese |
| author_facet | Edward J. Calabrese Vittorio Calabrese |
| author_sort | Edward J. Calabrese |
| collection | DOAJ |
| description | This paper provides an assessment of hormetic dose responses in epidermal stem cells (EpSCs) in animal models and humans, with emphasis on cell proliferation and differentiation and application to wound healing and aging processes. Hormetic dose responses were induced by several agents, including dietary supplements (eg, luteolin, quercetin), pharmaceuticals (eg, nitric oxide), endogenous agents (eg, growth/differentiation factor 5), and via diverse chemical means to sustain steaminess features to retard aging and disease onset. While hormetic dose responses have been extensively reported in a broad spectrum of stem cells, this area has only been explored to a limited extent in EpSCs, principally within the past 5 years. Nonetheless, these findings provide the first integrated assessment of hormesis and EpSC biology within the context of enhancing key functions such as cell proliferation and differentiation and resilience to inflammatory stresses. This paper assesses putative mechanisms of hormetic responses in EpSCs and potential therapeutic applications to prevent dermatological injury and disease. |
| first_indexed | 2024-04-11T11:22:36Z |
| format | Article |
| id | doaj.art-4fc95e979fef4f5b958fcebfae2eb74a |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-04-11T11:22:36Z |
| publishDate | 2022-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-4fc95e979fef4f5b958fcebfae2eb74a2022-12-22T04:26:43ZengSAGE PublishingDose-Response1559-32582022-09-012010.1177/15593258221119911Hormesis and Epidermal Stem CellsEdward J. CalabreseVittorio CalabreseThis paper provides an assessment of hormetic dose responses in epidermal stem cells (EpSCs) in animal models and humans, with emphasis on cell proliferation and differentiation and application to wound healing and aging processes. Hormetic dose responses were induced by several agents, including dietary supplements (eg, luteolin, quercetin), pharmaceuticals (eg, nitric oxide), endogenous agents (eg, growth/differentiation factor 5), and via diverse chemical means to sustain steaminess features to retard aging and disease onset. While hormetic dose responses have been extensively reported in a broad spectrum of stem cells, this area has only been explored to a limited extent in EpSCs, principally within the past 5 years. Nonetheless, these findings provide the first integrated assessment of hormesis and EpSC biology within the context of enhancing key functions such as cell proliferation and differentiation and resilience to inflammatory stresses. This paper assesses putative mechanisms of hormetic responses in EpSCs and potential therapeutic applications to prevent dermatological injury and disease.https://doi.org/10.1177/15593258221119911 |
| spellingShingle | Edward J. Calabrese Vittorio Calabrese Hormesis and Epidermal Stem Cells Dose-Response |
| title | Hormesis and Epidermal Stem Cells |
| title_full | Hormesis and Epidermal Stem Cells |
| title_fullStr | Hormesis and Epidermal Stem Cells |
| title_full_unstemmed | Hormesis and Epidermal Stem Cells |
| title_short | Hormesis and Epidermal Stem Cells |
| title_sort | hormesis and epidermal stem cells |
| url | https://doi.org/10.1177/15593258221119911 |
| work_keys_str_mv | AT edwardjcalabrese hormesisandepidermalstemcells AT vittoriocalabrese hormesisandepidermalstemcells |