EPDR1 levels and tumor budding predict and affect the prognosis of bladder carcinoma
BackgroundBladder carcinoma is a common malignancy of the urinary system. The previous study showed that EPDR1 expression was significantly related to the carcinogenesis and progression of bladder carcinomaMethodsWe retrospectively reviewed the records of 621 patients who were newly diagnosed with b...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.986006/full |
| _version_ | 1811227025195663360 |
|---|---|
| author | Yue Yang Yue Yang Yue Yang Hong Xu Han Zhu Dan Yuan Hanchao Zhang Hanchao Zhang Hanchao Zhang Hanchao Zhang Zhengdao Liu Zhengdao Liu Faliang Zhao Faliang Zhao Guobiao Liang Guobiao Liang |
| author_facet | Yue Yang Yue Yang Yue Yang Hong Xu Han Zhu Dan Yuan Hanchao Zhang Hanchao Zhang Hanchao Zhang Hanchao Zhang Zhengdao Liu Zhengdao Liu Faliang Zhao Faliang Zhao Guobiao Liang Guobiao Liang |
| author_sort | Yue Yang |
| collection | DOAJ |
| description | BackgroundBladder carcinoma is a common malignancy of the urinary system. The previous study showed that EPDR1 expression was significantly related to the carcinogenesis and progression of bladder carcinomaMethodsWe retrospectively reviewed the records of 621 patients who were newly diagnosed with bladder carcinoma between January 2018 and August 2020 at The Affiliated Hospital of Zunyi Medical University. We conducted immunohistochemistry of EPDR1 in tumor tissues. Meanwhile, tumor budding evaluation was also carried out by 2 independent experienced pathologists.Results80 patients were included in this study with a median age of 66 years (range; 42–88 years). 45% of the patients (36/80) were non-muscle-invasive bladder carcinoma patients, while 55% of muscle-invasive bladder carcinoma(44/80). The follow-up time was from 6 months to 36 months. We found that there were significant differences in expression of EPDR1 in the tumor pT stages(p<0.05), pM stages(p<0.05), and pN stages(p<0.05). Meanwhile, a higher expression of EPDR1 indicated a worse outcome for the patient(p<0.05). A tendency toward a worse status of the patient was accompanied by a high positive rate (p<0.001). Moreover, the IOD of EPDR1 had a positive relationship with TB (p<0.05). Furthermore, we found that EPDR1 and tumor budding could be crucial factors for affecting the prognosis of bladder carcinoma, even better than pTMN(Riskscore=(0.724)* pT_stage +(4.960) *EPDR1+(4.312)*TB).ConclusionIn conclusion, bladder cancer patients with higher expression levels of EPDR1 had worse survival outcomes. The combination of TB and EPDR1 levels could predict the prognosis for muscle-invasive bladder cancer patients. |
| first_indexed | 2024-04-12T09:35:30Z |
| format | Article |
| id | doaj.art-4fcbd2a30c304554bac2ad06676ec18d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T09:35:30Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4fcbd2a30c304554bac2ad06676ec18d2022-12-22T03:38:15ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.986006986006EPDR1 levels and tumor budding predict and affect the prognosis of bladder carcinomaYue Yang0Yue Yang1Yue Yang2Hong Xu3Han Zhu4Dan Yuan5Hanchao Zhang6Hanchao Zhang7Hanchao Zhang8Hanchao Zhang9Zhengdao Liu10Zhengdao Liu11Faliang Zhao12Faliang Zhao13Guobiao Liang14Guobiao Liang15Department of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Urology, Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, ChinaMedical College of Soochow University, Suzhou, ChinaDepartment of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Urology, Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, ChinaMedical College of Soochow University, Suzhou, ChinaDepartment of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaMedical College of Soochow University, Suzhou, ChinaDepartment of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaMedical College of Soochow University, Suzhou, ChinaDepartment of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaMedical College of Soochow University, Suzhou, ChinaBackgroundBladder carcinoma is a common malignancy of the urinary system. The previous study showed that EPDR1 expression was significantly related to the carcinogenesis and progression of bladder carcinomaMethodsWe retrospectively reviewed the records of 621 patients who were newly diagnosed with bladder carcinoma between January 2018 and August 2020 at The Affiliated Hospital of Zunyi Medical University. We conducted immunohistochemistry of EPDR1 in tumor tissues. Meanwhile, tumor budding evaluation was also carried out by 2 independent experienced pathologists.Results80 patients were included in this study with a median age of 66 years (range; 42–88 years). 45% of the patients (36/80) were non-muscle-invasive bladder carcinoma patients, while 55% of muscle-invasive bladder carcinoma(44/80). The follow-up time was from 6 months to 36 months. We found that there were significant differences in expression of EPDR1 in the tumor pT stages(p<0.05), pM stages(p<0.05), and pN stages(p<0.05). Meanwhile, a higher expression of EPDR1 indicated a worse outcome for the patient(p<0.05). A tendency toward a worse status of the patient was accompanied by a high positive rate (p<0.001). Moreover, the IOD of EPDR1 had a positive relationship with TB (p<0.05). Furthermore, we found that EPDR1 and tumor budding could be crucial factors for affecting the prognosis of bladder carcinoma, even better than pTMN(Riskscore=(0.724)* pT_stage +(4.960) *EPDR1+(4.312)*TB).ConclusionIn conclusion, bladder cancer patients with higher expression levels of EPDR1 had worse survival outcomes. The combination of TB and EPDR1 levels could predict the prognosis for muscle-invasive bladder cancer patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.986006/fullbiomarkerEPDR1bladder cancerprognosistumor margin |
| spellingShingle | Yue Yang Yue Yang Yue Yang Hong Xu Han Zhu Dan Yuan Hanchao Zhang Hanchao Zhang Hanchao Zhang Hanchao Zhang Zhengdao Liu Zhengdao Liu Faliang Zhao Faliang Zhao Guobiao Liang Guobiao Liang EPDR1 levels and tumor budding predict and affect the prognosis of bladder carcinoma Frontiers in Oncology biomarker EPDR1 bladder cancer prognosis tumor margin |
| title | EPDR1 levels and tumor budding predict and affect the prognosis of bladder carcinoma |
| title_full | EPDR1 levels and tumor budding predict and affect the prognosis of bladder carcinoma |
| title_fullStr | EPDR1 levels and tumor budding predict and affect the prognosis of bladder carcinoma |
| title_full_unstemmed | EPDR1 levels and tumor budding predict and affect the prognosis of bladder carcinoma |
| title_short | EPDR1 levels and tumor budding predict and affect the prognosis of bladder carcinoma |
| title_sort | epdr1 levels and tumor budding predict and affect the prognosis of bladder carcinoma |
| topic | biomarker EPDR1 bladder cancer prognosis tumor margin |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.986006/full |
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