Novel Synthesis and Antitumor Evaluation of Polyfunctionally Substituted Heterocyclic Compounds Derived from 2-Cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide

Novel Synthesis and Antitumor Evaluation of Polyfunctionally Substituted Heterocyclic Compounds Derived from 2-Cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide

The reaction of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene with ethyl cyanoacetate gave 2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide. The latter was used to synthesize different heterocyclic derivatives comprising thiophene, thiazole, pyrazole, pyridine, pyrimidine,...

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Bibliographic Details
Main Authors: Amira E. Mahmoud, Maher H. Helal, Rafat M. Mohareb, Hoda Z. Shams
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Molecules
Subjects:
4,5,6,7-tetrahydrobenzo[b]thiophene
thiazole
pyrazole
pyridine
antitumor
Online Access:http://www.mdpi.com/1420-3049/16/1/52/

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