Antineoplastic effects of erufosine on Graffi myeloid tumour in hamsters
Cancer has become one of the most significant health challenges for both human and veterinary medicine. The present study examined the antineoplastic and antimetastatic activity of the novel membrane-targeting anticancer agent erufosine. The antitumour effects of erufosine on Graffi virus-induced ex...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
2021-09-01
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| Series: | Bulgarian Journal of Veterinary Medicine |
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| _version_ | 1818922473230434304 |
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| author | A. Georgieva R. Toshkova K. Todorova R. Tzoneva |
| author_facet | A. Georgieva R. Toshkova K. Todorova R. Tzoneva |
| author_sort | A. Georgieva |
| collection | DOAJ |
| description | Cancer has become one of the most significant health challenges for both human and veterinary medicine. The present study examined the antineoplastic and antimetastatic activity of the novel membrane-targeting anticancer agent erufosine. The antitumour effects of erufosine on Graffi virus-induced experimental myeloid tumour in hamsters was assessed by histopathological methods and evaluation of some biometric parameters of tumour growth. Two schemes of experimental antitumour therapy were applied one that started simultaneously with the tumour transplantation and a second one that started after the appearance of palpable tumours. The results demonstrated protective antitu-mour effect of erufosine, expressed by decrease of transplantability, tumour growth inhibition, sup-pression of metastatic activity and extension of mean survival time. The effectivity of the experimental therapy was more pronounced when it was started simultaneously with the transplantation of the tumour cells. Presented results suggest that erufosine is a promising drug candidate for treatment of haematological malignances. |
| first_indexed | 2024-12-20T01:54:06Z |
| format | Article |
| id | doaj.art-4fcdcd458d4a41f5a1bfa28ee4fe3611 |
| institution | Directory Open Access Journal |
| issn | 1311-1477 1313-3543 |
| language | English |
| last_indexed | 2024-12-20T01:54:06Z |
| publishDate | 2021-09-01 |
| publisher | Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria |
| record_format | Article |
| series | Bulgarian Journal of Veterinary Medicine |
| spelling | doaj.art-4fcdcd458d4a41f5a1bfa28ee4fe36112022-12-21T19:57:32ZengFaculty of Veterinary Medicine, Trakia University, Stara Zagora, BulgariaBulgarian Journal of Veterinary Medicine1311-14771313-35432021-09-0124344244910.15547/bjvm.2278Antineoplastic effects of erufosine on Graffi myeloid tumour in hamstersA. Georgieva0R. Toshkova1K. Todorova2R. Tzoneva3Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, BulgariaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, BulgariaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, BulgariaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, BulgariaCancer has become one of the most significant health challenges for both human and veterinary medicine. The present study examined the antineoplastic and antimetastatic activity of the novel membrane-targeting anticancer agent erufosine. The antitumour effects of erufosine on Graffi virus-induced experimental myeloid tumour in hamsters was assessed by histopathological methods and evaluation of some biometric parameters of tumour growth. Two schemes of experimental antitumour therapy were applied one that started simultaneously with the tumour transplantation and a second one that started after the appearance of palpable tumours. The results demonstrated protective antitu-mour effect of erufosine, expressed by decrease of transplantability, tumour growth inhibition, sup-pression of metastatic activity and extension of mean survival time. The effectivity of the experimental therapy was more pronounced when it was started simultaneously with the transplantation of the tumour cells. Presented results suggest that erufosine is a promising drug candidate for treatment of haematological malignances.alkylphosphocholinesantitumour activityerufosinemyeloid tumour |
| spellingShingle | A. Georgieva R. Toshkova K. Todorova R. Tzoneva Antineoplastic effects of erufosine on Graffi myeloid tumour in hamsters Bulgarian Journal of Veterinary Medicine alkylphosphocholines antitumour activity erufosine myeloid tumour |
| title | Antineoplastic effects of erufosine on Graffi myeloid tumour in hamsters |
| title_full | Antineoplastic effects of erufosine on Graffi myeloid tumour in hamsters |
| title_fullStr | Antineoplastic effects of erufosine on Graffi myeloid tumour in hamsters |
| title_full_unstemmed | Antineoplastic effects of erufosine on Graffi myeloid tumour in hamsters |
| title_short | Antineoplastic effects of erufosine on Graffi myeloid tumour in hamsters |
| title_sort | antineoplastic effects of erufosine on graffi myeloid tumour in hamsters |
| topic | alkylphosphocholines antitumour activity erufosine myeloid tumour |
| work_keys_str_mv | AT ageorgieva antineoplasticeffectsoferufosineongraffimyeloidtumourinhamsters AT rtoshkova antineoplasticeffectsoferufosineongraffimyeloidtumourinhamsters AT ktodorova antineoplasticeffectsoferufosineongraffimyeloidtumourinhamsters AT rtzoneva antineoplasticeffectsoferufosineongraffimyeloidtumourinhamsters |