P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of Literature
T-acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) is rare and aggressive leukemia. Philadelphia chromosome positive (Ph+) is the most common cytogenetic abnormality in chronic myeloid leukemia (CML) and B-acute lymphoblastic leukemia (B-ALL). Ph+ T-ALL is exceeding rare and has a the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-07-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://www.karger.com/Article/FullText/516270 |
| _version_ | 1818922637865254912 |
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| author | Samah Kohla Sarah EL Kourashy Zafar Nawaz Reda Youssef Ahmad Al-Sabbagh Feryal A. Ibrahim |
| author_facet | Samah Kohla Sarah EL Kourashy Zafar Nawaz Reda Youssef Ahmad Al-Sabbagh Feryal A. Ibrahim |
| author_sort | Samah Kohla |
| collection | DOAJ |
| description | T-acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) is rare and aggressive leukemia. Philadelphia chromosome positive (Ph+) is the most common cytogenetic abnormality in chronic myeloid leukemia (CML) and B-acute lymphoblastic leukemia (B-ALL). Ph+ T-ALL is exceeding rare and has a therapeutic and prognostic significance. The incidence and outcome of Ph+ T-ALL are unknown. Differentiation between Ph+ T-ALL/LBL and T-cell lymphoblastic crises of CML may be difficult. We report a rare case of adult de novo T-ALL with significant monocytosis, having Ph+ with (P190 BCR-ABL1) as a cytogenetic abnormality. He was treated with ALL induction chemotherapy and imatinib and achieved complete remission, then relapsed twice and expired shortly after the last CNS relapse. |
| first_indexed | 2024-12-20T01:56:43Z |
| format | Article |
| id | doaj.art-4fce57d5a1cc4893b5f1257a4f243deb |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-20T01:56:43Z |
| publishDate | 2021-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-4fce57d5a1cc4893b5f1257a4f243deb2022-12-21T19:57:28ZengKarger PublishersCase Reports in Oncology1662-65752021-07-011421040105010.1159/000516270516270P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of LiteratureSamah Kohla0https://orcid.org/0000-0002-1050-9922Sarah EL Kourashy1Zafar Nawaz2Reda Youssef3Ahmad Al-Sabbagh4Feryal A. Ibrahim5Department of Lab Medicine and Pathology, Hematology Division, Hamad Medical Corporation, Doha, QatarDepartment of Hematology-Oncology, Hamad Medical Corporation, Doha, QatarDepartment of Lab Medicine and Pathology, Cytogenetic Division, Hamad Medical Corporation, Doha, QatarWeill Cornell Medicine, Doha, QatarDepartment of Lab Medicine and Pathology, Hematology Division, Hamad Medical Corporation, Doha, QatarDepartment of Lab Medicine and Pathology, Hematology Division, Hamad Medical Corporation, Doha, QatarT-acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) is rare and aggressive leukemia. Philadelphia chromosome positive (Ph+) is the most common cytogenetic abnormality in chronic myeloid leukemia (CML) and B-acute lymphoblastic leukemia (B-ALL). Ph+ T-ALL is exceeding rare and has a therapeutic and prognostic significance. The incidence and outcome of Ph+ T-ALL are unknown. Differentiation between Ph+ T-ALL/LBL and T-cell lymphoblastic crises of CML may be difficult. We report a rare case of adult de novo T-ALL with significant monocytosis, having Ph+ with (P190 BCR-ABL1) as a cytogenetic abnormality. He was treated with ALL induction chemotherapy and imatinib and achieved complete remission, then relapsed twice and expired shortly after the last CNS relapse.https://www.karger.com/Article/FullText/516270de novo t-allp190bcr-abl1 positive acute leukemiat-cell-acute lymphoblastic leukemiaphiladelphia positive acute leukemiaacute leukemiat-blastic phase of cml |
| spellingShingle | Samah Kohla Sarah EL Kourashy Zafar Nawaz Reda Youssef Ahmad Al-Sabbagh Feryal A. Ibrahim P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of Literature Case Reports in Oncology de novo t-all p190bcr-abl1 positive acute leukemia t-cell-acute lymphoblastic leukemia philadelphia positive acute leukemia acute leukemia t-blastic phase of cml |
| title | P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of Literature |
| title_full | P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of Literature |
| title_fullStr | P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of Literature |
| title_full_unstemmed | P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of Literature |
| title_short | P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of Literature |
| title_sort | p190bcr abl1 in a patient with philadelphia chromosome positive t cell acute lymphoblastic leukemia a rare case report and review of literature |
| topic | de novo t-all p190bcr-abl1 positive acute leukemia t-cell-acute lymphoblastic leukemia philadelphia positive acute leukemia acute leukemia t-blastic phase of cml |
| url | https://www.karger.com/Article/FullText/516270 |
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