Analgesic effect of dl-THP on inflammatory pain mediated by suppressing spinal TRPV1 and P2X3 receptors in rats

Analgesic effect of dl-THP on inflammatory pain mediated by suppressing spinal TRPV1 and P2X3 receptors in rats

Tetrahydropalmatine (dl-THP) demonstrates an analgesic effect in animal models of neuropathic and inflammatory pain, however, the underlying mechanisms of its pharmacological action within the spinal cord remains unclear. Both P2X3 receptor and TRPV1 are associated with the development and progressi...

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Bibliographic Details
Main Authors: Yan Wang, Rui-Rui Wang, Wei Sun, Chao Lou, Fan Yang, Ting He, Xiao-Liang Wang, Fa-Le Cao, Jun Chen
Format: Article
Language:English
Published: IMR Press 2021-04-01
Series:Frontiers in Bioscience-Landmark
Subjects:
inflammatory pain
dl-thp
trpv1
p2x3 receptor
Online Access:https://www.imrpress.com/journal/FBL/26/5/10.52586/4919

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