Chemical Composition and Evaluation of Antitumoral Activity of Leaf and Root Essential Oils of Conyza canadensis (Asteraceae)
The leaf and root oils of Conyza canadensis were studied for chemical composition and antitumor activity. The results showed that there is great variation in the composition of the oils obtained from different parts. The main components in the leaf oil were limonene, caryophyllene oxide and espatule...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Mato Grosso do Sul
2019-10-01
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| Series: | Orbital: The Electronic Journal of Chemistry |
| Subjects: | |
| Online Access: | https://periodicos.ufms.br/index.php/orbital/article/view/15847 |
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| author | Lucas W. Aragão Shaline S. L. Fernandes Viviane Mallmann Janaína Thomasi Facco Maria de Fátima Cepa Matos Marcia Regina Pereira Cabral João Ernesto de Carvalho Ana L. T. G. Ruiz Claudia Andréa Lima Cardoso Rogério Cesar de Lara da Silva Ademir dos Anjos Euclésio Simionatto |
| author_facet | Lucas W. Aragão Shaline S. L. Fernandes Viviane Mallmann Janaína Thomasi Facco Maria de Fátima Cepa Matos Marcia Regina Pereira Cabral João Ernesto de Carvalho Ana L. T. G. Ruiz Claudia Andréa Lima Cardoso Rogério Cesar de Lara da Silva Ademir dos Anjos Euclésio Simionatto |
| author_sort | Lucas W. Aragão |
| collection | DOAJ |
| description | The leaf and root oils of Conyza canadensis were studied for chemical composition and antitumor activity. The results showed that there is great variation in the composition of the oils obtained from different parts. The main components in the leaf oil were limonene, caryophyllene oxide and espatulenol. In the root oil the major component was the acetylenic ester lachnophyllum methyl ester. It was observed that according to the collection time (6 and 16 hours), significant variations in the content of the main components of this essential oil of leaves can occur. Limonene, spatulenol and caryophyllene oxide presented a distribution of 61% / 5.4% / 12.5% and 38% / 10.7% / 22.3% in oils obtained from plants collected at 6 and 16 hours, respectively. The antitumor activity of the oils showed that leaf oil had a greater potential for inhibition, and this oil was distinguished by the activity against neoplastic cell lines K562 (leukemia) and NCI-ADR / RES (ovary with multidrug resistance phenotype ) with TGI values of 16.8 and 19.0 mg.mL-1, respectively. Comparing the leaf oils and their tumor cell inhibition potentials, it was noted that this activity is higher in the oil with higher contents of monoterpene limonene.
DOI: http://dx.doi.org/10.17807/orbital.v11i5.1376
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| first_indexed | 2024-04-10T21:17:20Z |
| format | Article |
| id | doaj.art-4fcf21b3dd9f4758b046f3e6bce7628c |
| institution | Directory Open Access Journal |
| issn | 1984-6428 |
| language | English |
| last_indexed | 2024-04-10T21:17:20Z |
| publishDate | 2019-10-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj.art-4fcf21b3dd9f4758b046f3e6bce7628c2023-01-20T10:51:56ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282019-10-01115Chemical Composition and Evaluation of Antitumoral Activity of Leaf and Root Essential Oils of Conyza canadensis (Asteraceae)Lucas W. Aragão0Shaline S. L. Fernandes1Viviane Mallmann2Janaína Thomasi Facco3Maria de Fátima Cepa Matos4Marcia Regina Pereira Cabral5João Ernesto de Carvalho6Ana L. T. G. Ruiz7Claudia Andréa Lima Cardoso8Rogério Cesar de Lara da Silva9Ademir dos Anjos10Euclésio Simionatto11Universidade Estadual de Mato Grosso do SulUniversidade Estadual de Mato Grosso do SulUniversidade Estadual de Mato Grosso do SulUniversidade Estadual de Mato Grosso do SulUniversidade Federal de Mato Grosso do SulUniversidade Estadual de MaringáUniversidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de Mato Grosso do SulUniversidade Estadual de Mato Grosso do SulUniversidade Estadual de Mato Grosso do SulUniversidade Estadual de Mato Grosso do SulThe leaf and root oils of Conyza canadensis were studied for chemical composition and antitumor activity. The results showed that there is great variation in the composition of the oils obtained from different parts. The main components in the leaf oil were limonene, caryophyllene oxide and espatulenol. In the root oil the major component was the acetylenic ester lachnophyllum methyl ester. It was observed that according to the collection time (6 and 16 hours), significant variations in the content of the main components of this essential oil of leaves can occur. Limonene, spatulenol and caryophyllene oxide presented a distribution of 61% / 5.4% / 12.5% and 38% / 10.7% / 22.3% in oils obtained from plants collected at 6 and 16 hours, respectively. The antitumor activity of the oils showed that leaf oil had a greater potential for inhibition, and this oil was distinguished by the activity against neoplastic cell lines K562 (leukemia) and NCI-ADR / RES (ovary with multidrug resistance phenotype ) with TGI values of 16.8 and 19.0 mg.mL-1, respectively. Comparing the leaf oils and their tumor cell inhibition potentials, it was noted that this activity is higher in the oil with higher contents of monoterpene limonene. DOI: http://dx.doi.org/10.17807/orbital.v11i5.1376 https://periodicos.ufms.br/index.php/orbital/article/view/15847Conyza Canadensisessential oilantitumoral activitydiurnal variation |
| spellingShingle | Lucas W. Aragão Shaline S. L. Fernandes Viviane Mallmann Janaína Thomasi Facco Maria de Fátima Cepa Matos Marcia Regina Pereira Cabral João Ernesto de Carvalho Ana L. T. G. Ruiz Claudia Andréa Lima Cardoso Rogério Cesar de Lara da Silva Ademir dos Anjos Euclésio Simionatto Chemical Composition and Evaluation of Antitumoral Activity of Leaf and Root Essential Oils of Conyza canadensis (Asteraceae) Orbital: The Electronic Journal of Chemistry Conyza Canadensis essential oil antitumoral activity diurnal variation |
| title | Chemical Composition and Evaluation of Antitumoral Activity of Leaf and Root Essential Oils of Conyza canadensis (Asteraceae) |
| title_full | Chemical Composition and Evaluation of Antitumoral Activity of Leaf and Root Essential Oils of Conyza canadensis (Asteraceae) |
| title_fullStr | Chemical Composition and Evaluation of Antitumoral Activity of Leaf and Root Essential Oils of Conyza canadensis (Asteraceae) |
| title_full_unstemmed | Chemical Composition and Evaluation of Antitumoral Activity of Leaf and Root Essential Oils of Conyza canadensis (Asteraceae) |
| title_short | Chemical Composition and Evaluation of Antitumoral Activity of Leaf and Root Essential Oils of Conyza canadensis (Asteraceae) |
| title_sort | chemical composition and evaluation of antitumoral activity of leaf and root essential oils of conyza canadensis asteraceae |
| topic | Conyza Canadensis essential oil antitumoral activity diurnal variation |
| url | https://periodicos.ufms.br/index.php/orbital/article/view/15847 |
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