Rapid prototyping and design of cybergenetic single-cell controllers
Practical implementation of genetic circuits is difficult due to low predictability and time-intensive troubleshooting. Here the authors present Cyberloop, which interfaces a computer with single cells to enable cell-in-the-loop testing and optimization of circuit designs before they are built.
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25754-6 |
| _version_ | 1818431726276313088 |
|---|---|
| author | Sant Kumar Marc Rullan Mustafa Khammash |
| author_facet | Sant Kumar Marc Rullan Mustafa Khammash |
| author_sort | Sant Kumar |
| collection | DOAJ |
| description | Practical implementation of genetic circuits is difficult due to low predictability and time-intensive troubleshooting. Here the authors present Cyberloop, which interfaces a computer with single cells to enable cell-in-the-loop testing and optimization of circuit designs before they are built. |
| first_indexed | 2024-12-14T15:53:53Z |
| format | Article |
| id | doaj.art-4fcf3df15f76449dadbb49cc144fd3b4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:53:53Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4fcf3df15f76449dadbb49cc144fd3b42022-12-21T22:55:17ZengNature PortfolioNature Communications2041-17232021-09-0112111310.1038/s41467-021-25754-6Rapid prototyping and design of cybergenetic single-cell controllersSant Kumar0Marc Rullan1Mustafa Khammash2Department of Biosystems Science and Engineering (D-BSSE), ETH ZürichDepartment of Biosystems Science and Engineering (D-BSSE), ETH ZürichDepartment of Biosystems Science and Engineering (D-BSSE), ETH ZürichPractical implementation of genetic circuits is difficult due to low predictability and time-intensive troubleshooting. Here the authors present Cyberloop, which interfaces a computer with single cells to enable cell-in-the-loop testing and optimization of circuit designs before they are built.https://doi.org/10.1038/s41467-021-25754-6 |
| spellingShingle | Sant Kumar Marc Rullan Mustafa Khammash Rapid prototyping and design of cybergenetic single-cell controllers Nature Communications |
| title | Rapid prototyping and design of cybergenetic single-cell controllers |
| title_full | Rapid prototyping and design of cybergenetic single-cell controllers |
| title_fullStr | Rapid prototyping and design of cybergenetic single-cell controllers |
| title_full_unstemmed | Rapid prototyping and design of cybergenetic single-cell controllers |
| title_short | Rapid prototyping and design of cybergenetic single-cell controllers |
| title_sort | rapid prototyping and design of cybergenetic single cell controllers |
| url | https://doi.org/10.1038/s41467-021-25754-6 |
| work_keys_str_mv | AT santkumar rapidprototypinganddesignofcybergeneticsinglecellcontrollers AT marcrullan rapidprototypinganddesignofcybergeneticsinglecellcontrollers AT mustafakhammash rapidprototypinganddesignofcybergeneticsinglecellcontrollers |