Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives
Twenty-two 7-fluoro (or 8-methoxy)-4-anilinoquinolines compounds were designed and synthesized as potentially potent and selective antitumor inhibitors. All the prepared compounds were evaluated for their in vitro antiproliferative activities against the HeLa and BGC823 cell lines. Ten compounds (1a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/1/21 |
| _version_ | 1818562423582359552 |
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| author | Dan Liu Tian Luan Jian Kong Ying Zhang Hai-Feng Wang |
| author_facet | Dan Liu Tian Luan Jian Kong Ying Zhang Hai-Feng Wang |
| author_sort | Dan Liu |
| collection | DOAJ |
| description | Twenty-two 7-fluoro (or 8-methoxy)-4-anilinoquinolines compounds were designed and synthesized as potentially potent and selective antitumor inhibitors. All the prepared compounds were evaluated for their in vitro antiproliferative activities against the HeLa and BGC823 cell lines. Ten compounds (1a–g; 2c; 2e and 2i) exhibited excellent antitumor activity superior to that of gefitinib. Among the ten compounds; seven (1a–c; 1e–1g and 2i) displayed excellent selectivity for BGC823 cells. In particular; 1f and 2i exhibited potent cytotoxic activities against HeLa cells and BGC823 cells with better IC50 values than gefitinib. |
| first_indexed | 2024-12-14T01:03:33Z |
| format | Article |
| id | doaj.art-4fd0cfd48c90492bbddbf6482c251bf6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T01:03:33Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4fd0cfd48c90492bbddbf6482c251bf62022-12-21T23:23:06ZengMDPI AGMolecules1420-30492015-12-012112110.3390/molecules21010021molecules21010021Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline DerivativesDan Liu0Tian Luan1Jian Kong2Ying Zhang3Hai-Feng Wang4Department of Pharmaceutical Engineering, College of Parmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang 110142, ChinaDepartment of Pharmaceutical Engineering, College of Parmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang 110142, ChinaDepartment of Pharmaceutical Engineering, College of Parmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang 110142, ChinaDepartment of Pharmaceutical Engineering, College of Parmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang 110142, ChinaDepartment of Pharmaceutical Engineering, College of Parmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang 110142, ChinaTwenty-two 7-fluoro (or 8-methoxy)-4-anilinoquinolines compounds were designed and synthesized as potentially potent and selective antitumor inhibitors. All the prepared compounds were evaluated for their in vitro antiproliferative activities against the HeLa and BGC823 cell lines. Ten compounds (1a–g; 2c; 2e and 2i) exhibited excellent antitumor activity superior to that of gefitinib. Among the ten compounds; seven (1a–c; 1e–1g and 2i) displayed excellent selectivity for BGC823 cells. In particular; 1f and 2i exhibited potent cytotoxic activities against HeLa cells and BGC823 cells with better IC50 values than gefitinib.http://www.mdpi.com/1420-3049/21/1/214-anilinoquinolinesEGFRantitumorinhibitor |
| spellingShingle | Dan Liu Tian Luan Jian Kong Ying Zhang Hai-Feng Wang Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives Molecules 4-anilinoquinolines EGFR antitumor inhibitor |
| title | Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives |
| title_full | Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives |
| title_fullStr | Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives |
| title_full_unstemmed | Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives |
| title_short | Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives |
| title_sort | synthesis and anti tumor activities of 4 anilinoquinoline derivatives |
| topic | 4-anilinoquinolines EGFR antitumor inhibitor |
| url | http://www.mdpi.com/1420-3049/21/1/21 |
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