Structural and Electrophysiological Changes in a Model of Cardiotoxicity Induced by Anthracycline Combined With Trastuzumab

Structural and Electrophysiological Changes in a Model of Cardiotoxicity Induced by Anthracycline Combined With Trastuzumab

BackgroundCombined treatment with anthracyclines (e.g., doxorubicin; Dox) and trastuzumab (Trz), a humanized anti-human epidermal growth factor receptor 2 (HER2; ErbB2) antibody, in patients with HER2-positive cancer is limited by cardiotoxicity, as manifested by contractile dysfunction and arrhythm...

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Bibliographic Details
Main Authors: Claudia Altomare, Alessandra Maria Lodrini, Giuseppina Milano, Vanessa Biemmi, Edoardo Lazzarini, Sara Bolis, Nicolò Pernigoni, Eleonora Torre, Martina Arici, Mara Ferrandi, Lucio Barile, Marcella Rocchetti, Giuseppe Vassalli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Physiology
Subjects:
doxorubicin
trastuzumab
cardiotoxicity
T-tubules
electrophysiology
calcium handling
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.658790/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.658790/full

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