A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker
Background: Metastasis-Associated in Colon Cancer 1(<i>MACC1</i>) is a validated biomarker for metastasis and is linked to survival. Although extensive experimental evidence indicates an association between <i>MACC1</i> and diverse cancers, no pan-cancer analyses have yet be...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2021-09-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2021413?viewType=HTML |
| _version_ | 1818932636378202112 |
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| author | Ye Hu Meiling Wang Kainan Wang Jiyue Gao Jiaci Tong Zuowei Zhao Man Li |
| author_facet | Ye Hu Meiling Wang Kainan Wang Jiyue Gao Jiaci Tong Zuowei Zhao Man Li |
| author_sort | Ye Hu |
| collection | DOAJ |
| description | Background:
Metastasis-Associated in Colon Cancer 1(<i>MACC1</i>) is a validated biomarker for metastasis and is linked to survival. Although extensive experimental evidence indicates an association between <i>MACC1</i> and diverse cancers, no pan-cancer analyses have yet been performed for this marker, and the role of <i>MACC1</i> in immunology remains unknown.
Material and Methods:
In our study, we performed the analysis of <i>MACC1</i> expression and its influence on prognosis using multiple databases, including TIMER2, GEPIA2, Kaplan-Meier plotter. <i>MACC1</i> promoter methylation levels were evaluated using the UALCAN database. Based on the TCGA database, we explored the relationship between <i>MACC1</i> and tumor mutational burden (TMB), microsatellite instability (MSI), immune checkpoints using the R programming language. We evaluated the association between <i>MACC1</i> and immune infiltration via TIMER and UALCAN.
Results:
Our results revealed that abnormal DNA methylation may be an important cause for the different expression of <i>MACC1</i> across cancer types. Meanwhile, we explored the potential oncogenic roles of <i>MACC1</i> and found significant prognostic value. <i>MACC1</i> may be related to T-cell function and the polarization of tumor-associated macrophages, especially in STAD and LGG. Its expression was associated with immune infiltration and was found to be closely related to immune checkpoint-associated genes, especially CD274 and SIGLEC15, indicating that <i>MACC1</i> may be a potential immune therapeutic target for several malignancies. Our paper reveals for the first time the relationship between <i>MACC1</i> and cancer immunology.
Conclusions:
<i>MACC1</i> might act as a predictor for the immune response in cancer patients, and could also represent a new potential immunotherapeutic target. |
| first_indexed | 2024-12-20T04:35:38Z |
| format | Article |
| id | doaj.art-4fd2072c5b2744bc87a561d506433d97 |
| institution | Directory Open Access Journal |
| issn | 1551-0018 |
| language | English |
| last_indexed | 2024-12-20T04:35:38Z |
| publishDate | 2021-09-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj.art-4fd2072c5b2744bc87a561d506433d972022-12-21T19:53:17ZengAIMS PressMathematical Biosciences and Engineering1551-00182021-09-011868331835310.3934/mbe.2021413A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarkerYe Hu0Meiling Wang 1Kainan Wang 2Jiyue Gao3Jiaci Tong4Zuowei Zhao5Man Li6Department of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaDepartment of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaDepartment of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaDepartment of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaDepartment of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaDepartment of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaDepartment of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaBackground: Metastasis-Associated in Colon Cancer 1(<i>MACC1</i>) is a validated biomarker for metastasis and is linked to survival. Although extensive experimental evidence indicates an association between <i>MACC1</i> and diverse cancers, no pan-cancer analyses have yet been performed for this marker, and the role of <i>MACC1</i> in immunology remains unknown. Material and Methods: In our study, we performed the analysis of <i>MACC1</i> expression and its influence on prognosis using multiple databases, including TIMER2, GEPIA2, Kaplan-Meier plotter. <i>MACC1</i> promoter methylation levels were evaluated using the UALCAN database. Based on the TCGA database, we explored the relationship between <i>MACC1</i> and tumor mutational burden (TMB), microsatellite instability (MSI), immune checkpoints using the R programming language. We evaluated the association between <i>MACC1</i> and immune infiltration via TIMER and UALCAN. Results: Our results revealed that abnormal DNA methylation may be an important cause for the different expression of <i>MACC1</i> across cancer types. Meanwhile, we explored the potential oncogenic roles of <i>MACC1</i> and found significant prognostic value. <i>MACC1</i> may be related to T-cell function and the polarization of tumor-associated macrophages, especially in STAD and LGG. Its expression was associated with immune infiltration and was found to be closely related to immune checkpoint-associated genes, especially CD274 and SIGLEC15, indicating that <i>MACC1</i> may be a potential immune therapeutic target for several malignancies. Our paper reveals for the first time the relationship between <i>MACC1</i> and cancer immunology. Conclusions: <i>MACC1</i> might act as a predictor for the immune response in cancer patients, and could also represent a new potential immunotherapeutic target.https://www.aimspress.com/article/doi/10.3934/mbe.2021413?viewType=HTML<i>macc1</i>pan-cancer analysiscancer immunologybiomarkers |
| spellingShingle | Ye Hu Meiling Wang Kainan Wang Jiyue Gao Jiaci Tong Zuowei Zhao Man Li A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker Mathematical Biosciences and Engineering <i>macc1</i> pan-cancer analysis cancer immunology biomarkers |
| title | A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker |
| title_full | A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker |
| title_fullStr | A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker |
| title_full_unstemmed | A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker |
| title_short | A potential role for metastasis-associated in colon cancer 1 (<i>MACC1</i>) as a pan-cancer prognostic and immunological biomarker |
| title_sort | potential role for metastasis associated in colon cancer 1 i macc1 i as a pan cancer prognostic and immunological biomarker |
| topic | <i>macc1</i> pan-cancer analysis cancer immunology biomarkers |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2021413?viewType=HTML |
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