A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population
Abstract Background Adaptor-related protein complex 2 alpha 2 subunit (AP2A2) gene encodes a protein-a subunit of the AP-2 adaptor protein complex. Evidence has revealed that benzodiazepine receptor-associated protein 1 (BZRAP1) is abundant in the hippocampus with potential effects on brain diseases...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-018-0905-2 |
| _version_ | 1818243147838259200 |
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| author | Sibo Wang Zhihui Ma Yongjun Zhang Yankui Ding Zhong Chen Liansheng Wang |
| author_facet | Sibo Wang Zhihui Ma Yongjun Zhang Yankui Ding Zhong Chen Liansheng Wang |
| author_sort | Sibo Wang |
| collection | DOAJ |
| description | Abstract Background Adaptor-related protein complex 2 alpha 2 subunit (AP2A2) gene encodes a protein-a subunit of the AP-2 adaptor protein complex. Evidence has revealed that benzodiazepine receptor-associated protein 1 (BZRAP1) is abundant in the hippocampus with potential effects on brain diseases. Recently, an epidemiological study reported that two variants (rs7396366 and rs2526378) closest to the AP2A2 and BZRAP1 genes are associated with higher plasma lipids and Alzheimer’s disease. Whether the two single nucleotide polymorphisms (SNPs) are actually relevant to coronary artery disease (CAD) and CAD severity remains elusive. Our aim was to assess whether these two SNPs are relevant to CAD and its severity in a Chinese population. Methods Three hundred and thirty-five patients with documented CAD (282 stable CAD, 28 non-ST-segment elevation myocardial infarction, 25 ST-segment elevation myocardial infarction), and 372 non-CAD controls were included in the study. The participants were divided into two groups according to coronary angiography results. CAD patients were further demarcated into subgroups with one-, two-, or three-vessel stenosis. Genotypes at rs7396366 and rs2526378 were examined using polymerase chain reaction-ligase detection reaction. The association between these two SNPs with CAD and its severity were analyzed. Results The frequency of the rs7396366 TT genotype was significantly higher in CAD patients than in controls (13.7% vs. 7.8%, 95% CI: 1.15–3.07, P = 0.014). Subjects with a variant genotype T allele had an increased risk of CAD compared with G allele carriers (additive model: 95% CI: 1.21–3.35, P = 0.008). After adjustment for traditional cardiovascular risk factors, analysis of the dominant models involving rs7396366 also showed that T allele carriers had a significantly higher risk for CAD than G allele carriers had (dominant model: OR 1.48, 95% CI: 1.03–2.14, P = 0.035). Age, sex, type 2 diabetes mellitus, fasting plasma glucose, and the TT genotype in rs7396366 were significantly associated with three-vessel lesions. Despite these significant outcomes of rs7396366, information on rs2526378 showed no significant difference between CAD patients and non-CAD controls. Conclusion Our results show that the T allele and TT genotype in rs7396366, closest to the AP2A2 gene, are linked to an increased risk of CAD and its severity in a Chinese population. |
| first_indexed | 2024-12-12T13:56:31Z |
| format | Article |
| id | doaj.art-4fd4e05005b141d1a1f0ed0c66736727 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-12T13:56:31Z |
| publishDate | 2018-08-01 |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-4fd4e05005b141d1a1f0ed0c667367272022-12-22T00:22:27ZengBMCBMC Cardiovascular Disorders1471-22612018-08-011811810.1186/s12872-018-0905-2A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese populationSibo Wang0Zhihui Ma1Yongjun Zhang2Yankui Ding3Zhong Chen4Liansheng Wang5Department of Cardiology, the First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiology, Affiliated Sixth People’s Hospital East of Shanghai University of Medicine and Health SciencesDepartment of Cardiology, Affiliated Sixth People’s Hospital East of Shanghai University of Medicine and Health SciencesDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiology, Affiliated Sixth People’s Hospital East of Shanghai University of Medicine and Health SciencesDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical UniversityAbstract Background Adaptor-related protein complex 2 alpha 2 subunit (AP2A2) gene encodes a protein-a subunit of the AP-2 adaptor protein complex. Evidence has revealed that benzodiazepine receptor-associated protein 1 (BZRAP1) is abundant in the hippocampus with potential effects on brain diseases. Recently, an epidemiological study reported that two variants (rs7396366 and rs2526378) closest to the AP2A2 and BZRAP1 genes are associated with higher plasma lipids and Alzheimer’s disease. Whether the two single nucleotide polymorphisms (SNPs) are actually relevant to coronary artery disease (CAD) and CAD severity remains elusive. Our aim was to assess whether these two SNPs are relevant to CAD and its severity in a Chinese population. Methods Three hundred and thirty-five patients with documented CAD (282 stable CAD, 28 non-ST-segment elevation myocardial infarction, 25 ST-segment elevation myocardial infarction), and 372 non-CAD controls were included in the study. The participants were divided into two groups according to coronary angiography results. CAD patients were further demarcated into subgroups with one-, two-, or three-vessel stenosis. Genotypes at rs7396366 and rs2526378 were examined using polymerase chain reaction-ligase detection reaction. The association between these two SNPs with CAD and its severity were analyzed. Results The frequency of the rs7396366 TT genotype was significantly higher in CAD patients than in controls (13.7% vs. 7.8%, 95% CI: 1.15–3.07, P = 0.014). Subjects with a variant genotype T allele had an increased risk of CAD compared with G allele carriers (additive model: 95% CI: 1.21–3.35, P = 0.008). After adjustment for traditional cardiovascular risk factors, analysis of the dominant models involving rs7396366 also showed that T allele carriers had a significantly higher risk for CAD than G allele carriers had (dominant model: OR 1.48, 95% CI: 1.03–2.14, P = 0.035). Age, sex, type 2 diabetes mellitus, fasting plasma glucose, and the TT genotype in rs7396366 were significantly associated with three-vessel lesions. Despite these significant outcomes of rs7396366, information on rs2526378 showed no significant difference between CAD patients and non-CAD controls. Conclusion Our results show that the T allele and TT genotype in rs7396366, closest to the AP2A2 gene, are linked to an increased risk of CAD and its severity in a Chinese population.http://link.springer.com/article/10.1186/s12872-018-0905-2SNP, single nucleotide polymorphismAssociationrs7396366rs2526378CAD, coronary artery diseaseSusceptibility |
| spellingShingle | Sibo Wang Zhihui Ma Yongjun Zhang Yankui Ding Zhong Chen Liansheng Wang A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population BMC Cardiovascular Disorders SNP, single nucleotide polymorphism Association rs7396366 rs2526378 CAD, coronary artery disease Susceptibility |
| title | A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population |
| title_full | A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population |
| title_fullStr | A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population |
| title_full_unstemmed | A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population |
| title_short | A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population |
| title_sort | genetic variant near adaptor related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a chinese population |
| topic | SNP, single nucleotide polymorphism Association rs7396366 rs2526378 CAD, coronary artery disease Susceptibility |
| url | http://link.springer.com/article/10.1186/s12872-018-0905-2 |
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