Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro
The following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/13/7/1771 |
| _version_ | 1797571029645656064 |
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| author | Bartosz Maciejewski Vishnu Arumughan Anette Larsson Małgorzata Sznitowska |
| author_facet | Bartosz Maciejewski Vishnu Arumughan Anette Larsson Małgorzata Sznitowska |
| author_sort | Bartosz Maciejewski |
| collection | DOAJ |
| description | The following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer films was performed. The results suggest that the critical feature behind formation of the acid-resistant films is a spinodal decomposition in the film-forming mixture. In the obtained films, upon submersion in an acidic medium, gelatin swells and dissolves, exposing a CAP-based acid-insoluble skeleton, partially coated by a residue of other ingredients. The dissolution-hindering effect appears to be stronger when iota-carrageenan is added to the film-forming mixture. The drug release study performed in enhancer cells confirmed that diclofenac sodium is not released in the acidic medium, however, at pH 6.8 the drug release occurs. The capsules prepared with a simple lab-scale process appear to be resistant to disintegration of the shell structure in acid, although imperfections of the sealing have been noticed. |
| first_indexed | 2024-03-10T20:33:48Z |
| format | Article |
| id | doaj.art-4fd88448af9a4139a76b8ad3a5df4215 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T20:33:48Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-4fd88448af9a4139a76b8ad3a5df42152023-11-19T21:10:34ZengMDPI AGMaterials1996-19442020-04-01137177110.3390/ma13071771Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In VitroBartosz Maciejewski0Vishnu Arumughan1Anette Larsson2Małgorzata Sznitowska3Department of Pharmaceutical Technology, Medical University of Gdansk, 80-416 Gdansk, PolandDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, 412 96 Gothenburg, SwedenDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, 412 96 Gothenburg, SwedenDepartment of Pharmaceutical Technology, Medical University of Gdansk, 80-416 Gdansk, PolandThe following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer films was performed. The results suggest that the critical feature behind formation of the acid-resistant films is a spinodal decomposition in the film-forming mixture. In the obtained films, upon submersion in an acidic medium, gelatin swells and dissolves, exposing a CAP-based acid-insoluble skeleton, partially coated by a residue of other ingredients. The dissolution-hindering effect appears to be stronger when iota-carrageenan is added to the film-forming mixture. The drug release study performed in enhancer cells confirmed that diclofenac sodium is not released in the acidic medium, however, at pH 6.8 the drug release occurs. The capsules prepared with a simple lab-scale process appear to be resistant to disintegration of the shell structure in acid, although imperfections of the sealing have been noticed.https://www.mdpi.com/1996-1944/13/7/1771gelatingastro-resistantfilmscapsulesstructuredrug release |
| spellingShingle | Bartosz Maciejewski Vishnu Arumughan Anette Larsson Małgorzata Sznitowska Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro Materials gelatin gastro-resistant films capsules structure drug release |
| title | Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
| title_full | Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
| title_fullStr | Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
| title_full_unstemmed | Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
| title_short | Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro |
| title_sort | prototype gastro resistant soft gelatin films and capsules imaging and performance in vitro |
| topic | gelatin gastro-resistant films capsules structure drug release |
| url | https://www.mdpi.com/1996-1944/13/7/1771 |
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