Mid-Term Results of Single-Stage Surgery for Patients with Chronic Osteomyelitis Using Antibiotic-Loaded Resorbable PerOssal<sup>®</sup> Beads
This retrospective study reports on the treatment of chronic osteomyelitis with local debridement combined with PerOssal<sup>®</sup>. The diagnosis of chronic osteomyelitis was confirmed in all cases and classified according to the Cierny–Mader (C-M) classification. The primary outcome w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/7/1623 |
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| author | Andrea Sambri Luca Cevolani Valentina Passarino Marta Bortoli Stefania Claudia Parisi Michele Fiore Laura Campanacci Eric Staals Davide Maria Donati Massimiliano De Paolis |
| author_facet | Andrea Sambri Luca Cevolani Valentina Passarino Marta Bortoli Stefania Claudia Parisi Michele Fiore Laura Campanacci Eric Staals Davide Maria Donati Massimiliano De Paolis |
| author_sort | Andrea Sambri |
| collection | DOAJ |
| description | This retrospective study reports on the treatment of chronic osteomyelitis with local debridement combined with PerOssal<sup>®</sup>. The diagnosis of chronic osteomyelitis was confirmed in all cases and classified according to the Cierny–Mader (C-M) classification. The primary outcome was the eradication of infection at a minimum of one year after surgery. A total of 93 patients (median age: 40 years) were included. The most represented sites were the femur (24, 25.8%) and tibia (52, 55.9%). Twenty-six patients (28.0%) had significant local or systemic comorbidities (C-M Class B hosts). According to anatomic type, 31 cases were type I, 13 type II, 21 type III and 28 type IV. Vancomycin was added to PerOssal<sup>®</sup> in most cases (80, 86.0%). In 24 (25.8%) cases, Vancomycin and Rifampicin were combined. In 32 (34.4%) cases, intraoperative cultures were negative. <i>Staphylococcus aureus</i> was isolated in 39 (63.9%) patients, and Gram-negative bacteria were isolated in 12 cases. The median follow-up was 21 months (range 12–84). A total of 21 (22.6%) patients developed an infection recurrence (IR) after a median follow-up of 11 months (range: 1–47). PerOssal<sup>®</sup> holds several practical advantages compared to other bone void fillers. Thus, due to its good biocompatibility and sufficient antibiotic release, it represents a viable adjuvant treatment in chronic osteomyelitis. |
| first_indexed | 2024-03-11T00:48:42Z |
| format | Article |
| id | doaj.art-4fda224c16484c2fac1e00e8442547fb |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T00:48:42Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-4fda224c16484c2fac1e00e8442547fb2023-11-18T20:34:07ZengMDPI AGMicroorganisms2076-26072023-06-01117162310.3390/microorganisms11071623Mid-Term Results of Single-Stage Surgery for Patients with Chronic Osteomyelitis Using Antibiotic-Loaded Resorbable PerOssal<sup>®</sup> BeadsAndrea Sambri0Luca Cevolani1Valentina Passarino2Marta Bortoli3Stefania Claudia Parisi4Michele Fiore5Laura Campanacci6Eric Staals7Davide Maria Donati8Massimiliano De Paolis9Orthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopedic Oncology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyOrthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopedic Oncology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyOrthopedic Oncology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyOrthopedic Oncology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyOrthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyThis retrospective study reports on the treatment of chronic osteomyelitis with local debridement combined with PerOssal<sup>®</sup>. The diagnosis of chronic osteomyelitis was confirmed in all cases and classified according to the Cierny–Mader (C-M) classification. The primary outcome was the eradication of infection at a minimum of one year after surgery. A total of 93 patients (median age: 40 years) were included. The most represented sites were the femur (24, 25.8%) and tibia (52, 55.9%). Twenty-six patients (28.0%) had significant local or systemic comorbidities (C-M Class B hosts). According to anatomic type, 31 cases were type I, 13 type II, 21 type III and 28 type IV. Vancomycin was added to PerOssal<sup>®</sup> in most cases (80, 86.0%). In 24 (25.8%) cases, Vancomycin and Rifampicin were combined. In 32 (34.4%) cases, intraoperative cultures were negative. <i>Staphylococcus aureus</i> was isolated in 39 (63.9%) patients, and Gram-negative bacteria were isolated in 12 cases. The median follow-up was 21 months (range 12–84). A total of 21 (22.6%) patients developed an infection recurrence (IR) after a median follow-up of 11 months (range: 1–47). PerOssal<sup>®</sup> holds several practical advantages compared to other bone void fillers. Thus, due to its good biocompatibility and sufficient antibiotic release, it represents a viable adjuvant treatment in chronic osteomyelitis.https://www.mdpi.com/2076-2607/11/7/1623perossalchronic osteomyelitisbone fillerantibioticcalcium sulfate |
| spellingShingle | Andrea Sambri Luca Cevolani Valentina Passarino Marta Bortoli Stefania Claudia Parisi Michele Fiore Laura Campanacci Eric Staals Davide Maria Donati Massimiliano De Paolis Mid-Term Results of Single-Stage Surgery for Patients with Chronic Osteomyelitis Using Antibiotic-Loaded Resorbable PerOssal<sup>®</sup> Beads Microorganisms perossal chronic osteomyelitis bone filler antibiotic calcium sulfate |
| title | Mid-Term Results of Single-Stage Surgery for Patients with Chronic Osteomyelitis Using Antibiotic-Loaded Resorbable PerOssal<sup>®</sup> Beads |
| title_full | Mid-Term Results of Single-Stage Surgery for Patients with Chronic Osteomyelitis Using Antibiotic-Loaded Resorbable PerOssal<sup>®</sup> Beads |
| title_fullStr | Mid-Term Results of Single-Stage Surgery for Patients with Chronic Osteomyelitis Using Antibiotic-Loaded Resorbable PerOssal<sup>®</sup> Beads |
| title_full_unstemmed | Mid-Term Results of Single-Stage Surgery for Patients with Chronic Osteomyelitis Using Antibiotic-Loaded Resorbable PerOssal<sup>®</sup> Beads |
| title_short | Mid-Term Results of Single-Stage Surgery for Patients with Chronic Osteomyelitis Using Antibiotic-Loaded Resorbable PerOssal<sup>®</sup> Beads |
| title_sort | mid term results of single stage surgery for patients with chronic osteomyelitis using antibiotic loaded resorbable perossal sup r sup beads |
| topic | perossal chronic osteomyelitis bone filler antibiotic calcium sulfate |
| url | https://www.mdpi.com/2076-2607/11/7/1623 |
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