Mitochondrial transfer - a novel promising approach for the treatment of metabolic diseases
Metabolic disorders remain a major global health concern in the 21st century, with increasing incidence and prevalence. Mitochondria play a critical role in cellular energy production, calcium homeostasis, signal transduction, and apoptosis. Under physiological conditions, mitochondrial transfer pla...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1346441/full |
| _version_ | 1797351620533551104 |
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| author | Ruijing Chen Jun Chen Jun Chen Jun Chen Jun Chen |
| author_facet | Ruijing Chen Jun Chen Jun Chen Jun Chen Jun Chen |
| author_sort | Ruijing Chen |
| collection | DOAJ |
| description | Metabolic disorders remain a major global health concern in the 21st century, with increasing incidence and prevalence. Mitochondria play a critical role in cellular energy production, calcium homeostasis, signal transduction, and apoptosis. Under physiological conditions, mitochondrial transfer plays a crucial role in tissue homeostasis and development. Mitochondrial dysfunction has been implicated in the pathogenesis of metabolic disorders. Numerous studies have demonstrated that mitochondria can be transferred from stem cells to pathologically injured cells, leading to mitochondrial functional restoration. Compared to cell therapy, mitochondrial transplantation has lower immunogenicity, making exogenous transplantation of healthy mitochondria a promising therapeutic approach for treating diseases, particularly metabolic disorders. This review summarizes the association between metabolic disorders and mitochondria, the mechanisms of mitochondrial transfer, and the therapeutic potential of mitochondrial transfer for metabolic disorders. We hope this review provides novel insights into targeted mitochondrial therapy for metabolic disorders. |
| first_indexed | 2024-03-08T13:03:08Z |
| format | Article |
| id | doaj.art-4fdb6a539f6346409507518768d04d20 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T13:03:08Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4fdb6a539f6346409507518768d04d202024-01-19T04:29:09ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.13464411346441Mitochondrial transfer - a novel promising approach for the treatment of metabolic diseasesRuijing Chen0Jun Chen1Jun Chen2Jun Chen3Jun Chen4Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaInstitute of Endocrine and Metabolic Diseases of Shandong University, Jinan, Shandong, ChinaKey Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine and Health, Jinan, Shandong, ChinaJinan Clinical Research Center for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaMetabolic disorders remain a major global health concern in the 21st century, with increasing incidence and prevalence. Mitochondria play a critical role in cellular energy production, calcium homeostasis, signal transduction, and apoptosis. Under physiological conditions, mitochondrial transfer plays a crucial role in tissue homeostasis and development. Mitochondrial dysfunction has been implicated in the pathogenesis of metabolic disorders. Numerous studies have demonstrated that mitochondria can be transferred from stem cells to pathologically injured cells, leading to mitochondrial functional restoration. Compared to cell therapy, mitochondrial transplantation has lower immunogenicity, making exogenous transplantation of healthy mitochondria a promising therapeutic approach for treating diseases, particularly metabolic disorders. This review summarizes the association between metabolic disorders and mitochondria, the mechanisms of mitochondrial transfer, and the therapeutic potential of mitochondrial transfer for metabolic disorders. We hope this review provides novel insights into targeted mitochondrial therapy for metabolic disorders.https://www.frontiersin.org/articles/10.3389/fendo.2023.1346441/fullmitochondriamitochondrial transfertransplantationmetabolic diseasestherapy |
| spellingShingle | Ruijing Chen Jun Chen Jun Chen Jun Chen Jun Chen Mitochondrial transfer - a novel promising approach for the treatment of metabolic diseases Frontiers in Endocrinology mitochondria mitochondrial transfer transplantation metabolic diseases therapy |
| title | Mitochondrial transfer - a novel promising approach for the treatment of metabolic diseases |
| title_full | Mitochondrial transfer - a novel promising approach for the treatment of metabolic diseases |
| title_fullStr | Mitochondrial transfer - a novel promising approach for the treatment of metabolic diseases |
| title_full_unstemmed | Mitochondrial transfer - a novel promising approach for the treatment of metabolic diseases |
| title_short | Mitochondrial transfer - a novel promising approach for the treatment of metabolic diseases |
| title_sort | mitochondrial transfer a novel promising approach for the treatment of metabolic diseases |
| topic | mitochondria mitochondrial transfer transplantation metabolic diseases therapy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1346441/full |
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