The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition
Autoinhibition ensures the proper spatiotemporal control of the kinesin-3 motor activity. Here, the authors present the full-length structure of kinesin-3 KLP-6 in an autoinhibited state and observe that all the internal domains entwine around the motor domain via a multilevel-lockdown mechanism.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32048-y |
| Summary: | Autoinhibition ensures the proper spatiotemporal control of the kinesin-3 motor activity. Here, the authors present the full-length structure of kinesin-3 KLP-6 in an autoinhibited state and observe that all the internal domains entwine around the motor domain via a multilevel-lockdown mechanism. |
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| ISSN: | 2041-1723 |