Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic
AimPreviously, neuroimaging studies on comorbid Posttraumatic-Major depression disorder (PTSD-MDD) comorbidity found abnormalities in multiple brain regions among patients. Recent neuroimaging studies have revealed dynamic nature on human brain activity during resting state, and entropy as an indica...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1143780/full |
| _version_ | 1827935590038896640 |
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| author | Shishun Fu Sipei Liang Chulan Lin Yunfan Wu Shuangcong Xie Meng Li Qiang Lei Jianneng Li Kanghui Yu Yi Yin Kelei Hua Wuming Li Caojun Wu Xiaofen Ma Guihua Jiang |
| author_facet | Shishun Fu Sipei Liang Chulan Lin Yunfan Wu Shuangcong Xie Meng Li Qiang Lei Jianneng Li Kanghui Yu Yi Yin Kelei Hua Wuming Li Caojun Wu Xiaofen Ma Guihua Jiang |
| author_sort | Shishun Fu |
| collection | DOAJ |
| description | AimPreviously, neuroimaging studies on comorbid Posttraumatic-Major depression disorder (PTSD-MDD) comorbidity found abnormalities in multiple brain regions among patients. Recent neuroimaging studies have revealed dynamic nature on human brain activity during resting state, and entropy as an indicator of dynamic regularity may provide a new perspective for studying abnormalities of brain function among PTSD-MDD patients. During the COVID-19 pandemic, there has been a significant increase in the number of patients with PTSD-MDD. We have decided to conduct research on resting-state brain functional activity of patients who developed PTSD-MDD during this period using entropy.MethodsThirty three patients with PTSD-MDD and 36 matched TCs were recruited. PTSD and depression symptoms were assessed using multiple clinical scales. All subjects underwent functional magnetic resonance imaging (fMRI) scans. And the brain entropy (BEN) maps were calculated using the BEN mapping toolbox. A two-sample t-test was used to compare the differences in the brain entropy between the PTSD-MDD comorbidity group and TC group. Furthermore, correlation analysis was conducted between the BEN changes in patients with PTSD-MDD and clinical scales.ResultsCompared to the TCs, PTSD-MDD patients had a reduced BEN in the right middle frontal orbital gyrus (R_MFOG), left putamen, and right inferior frontal gyrus, opercular part (R_IFOG). Furthermore, a higher BEN in the R_MFOG was related to higher CAPS and HAMD-24 scores in the patients with PTSD-MDD.ConclusionThe results showed that the R_MFOG is a potential marker for showing the symptom severity of PTSD-MDD comorbidity. Consequently, PTSD-MDD may have reduced BEN in frontal and basal ganglia regions which are related to emotional dysregulation and cognitive deficits. |
| first_indexed | 2024-03-13T07:56:02Z |
| format | Article |
| id | doaj.art-4fdbf041994e44cc821fe7f6f967b610 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-13T07:56:02Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-4fdbf041994e44cc821fe7f6f967b6102023-06-02T04:34:09ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-06-011410.3389/fpsyt.2023.11437801143780Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemicShishun Fu0Sipei Liang1Chulan Lin2Yunfan Wu3Shuangcong Xie4Meng Li5Qiang Lei6Jianneng Li7Kanghui Yu8Yi Yin9Kelei Hua10Wuming Li11Caojun Wu12Xiaofen Ma13Guihua Jiang14The Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe Department of Nuclear Medicine, Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou, ChinaAimPreviously, neuroimaging studies on comorbid Posttraumatic-Major depression disorder (PTSD-MDD) comorbidity found abnormalities in multiple brain regions among patients. Recent neuroimaging studies have revealed dynamic nature on human brain activity during resting state, and entropy as an indicator of dynamic regularity may provide a new perspective for studying abnormalities of brain function among PTSD-MDD patients. During the COVID-19 pandemic, there has been a significant increase in the number of patients with PTSD-MDD. We have decided to conduct research on resting-state brain functional activity of patients who developed PTSD-MDD during this period using entropy.MethodsThirty three patients with PTSD-MDD and 36 matched TCs were recruited. PTSD and depression symptoms were assessed using multiple clinical scales. All subjects underwent functional magnetic resonance imaging (fMRI) scans. And the brain entropy (BEN) maps were calculated using the BEN mapping toolbox. A two-sample t-test was used to compare the differences in the brain entropy between the PTSD-MDD comorbidity group and TC group. Furthermore, correlation analysis was conducted between the BEN changes in patients with PTSD-MDD and clinical scales.ResultsCompared to the TCs, PTSD-MDD patients had a reduced BEN in the right middle frontal orbital gyrus (R_MFOG), left putamen, and right inferior frontal gyrus, opercular part (R_IFOG). Furthermore, a higher BEN in the R_MFOG was related to higher CAPS and HAMD-24 scores in the patients with PTSD-MDD.ConclusionThe results showed that the R_MFOG is a potential marker for showing the symptom severity of PTSD-MDD comorbidity. Consequently, PTSD-MDD may have reduced BEN in frontal and basal ganglia regions which are related to emotional dysregulation and cognitive deficits.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1143780/fullposttraumatic stress disordermajor depressive disorderbrain entropyfMRIresting-state |
| spellingShingle | Shishun Fu Sipei Liang Chulan Lin Yunfan Wu Shuangcong Xie Meng Li Qiang Lei Jianneng Li Kanghui Yu Yi Yin Kelei Hua Wuming Li Caojun Wu Xiaofen Ma Guihua Jiang Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic Frontiers in Psychiatry posttraumatic stress disorder major depressive disorder brain entropy fMRI resting-state |
| title | Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic |
| title_full | Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic |
| title_fullStr | Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic |
| title_full_unstemmed | Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic |
| title_short | Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic |
| title_sort | aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic |
| topic | posttraumatic stress disorder major depressive disorder brain entropy fMRI resting-state |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1143780/full |
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