Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals
Abstract Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12958-018-0334-1 |
| _version_ | 1818619926154313728 |
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| author | Xiaodan Cao Yun Cui Xiaoxia Zhang Jiangtao Lou Jun Zhou Huafeng Bei Renxiong Wei |
| author_facet | Xiaodan Cao Yun Cui Xiaoxia Zhang Jiangtao Lou Jun Zhou Huafeng Bei Renxiong Wei |
| author_sort | Xiaodan Cao |
| collection | DOAJ |
| description | Abstract Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal plasma in asthenozoospermia and considered post-translational modifications in spermatozoa of asthenozoospermia. The reduction of sperm motility in asthenozoospermic patients had been attributed to factors, for instance, energy metabolism dysfunction or structural defects in the sperm-tail protein components and the differential proteins potentially involved in sperm motility such as COX6B, ODF, TUBB2B were described. Comparative proteomic analysis open a window to discover the potential pathogenic mechanisms of asthenozoospermia and the biomarkers with clinical significance. |
| first_indexed | 2024-12-16T17:45:14Z |
| format | Article |
| id | doaj.art-4fe063794a134f93ba071d064eb6995f |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-16T17:45:14Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-4fe063794a134f93ba071d064eb6995f2022-12-21T22:22:30ZengBMCReproductive Biology and Endocrinology1477-78272018-02-011611810.1186/s12958-018-0334-1Proteomic profile of human spermatozoa in healthy and asthenozoospermic individualsXiaodan Cao0Yun Cui1Xiaoxia Zhang2Jiangtao Lou3Jun Zhou4Huafeng Bei5Renxiong Wei6Department of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese MedicineDepartment of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese MedicineDepartment of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese MedicineDepartment of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese MedicineDepartment of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese MedicineDepartment of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese MedicineDepartment of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese MedicineAbstract Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal plasma in asthenozoospermia and considered post-translational modifications in spermatozoa of asthenozoospermia. The reduction of sperm motility in asthenozoospermic patients had been attributed to factors, for instance, energy metabolism dysfunction or structural defects in the sperm-tail protein components and the differential proteins potentially involved in sperm motility such as COX6B, ODF, TUBB2B were described. Comparative proteomic analysis open a window to discover the potential pathogenic mechanisms of asthenozoospermia and the biomarkers with clinical significance.http://link.springer.com/article/10.1186/s12958-018-0334-1ProteomeSpermatozoaSperm motilityAsthenozoospermiaInfertility |
| spellingShingle | Xiaodan Cao Yun Cui Xiaoxia Zhang Jiangtao Lou Jun Zhou Huafeng Bei Renxiong Wei Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals Reproductive Biology and Endocrinology Proteome Spermatozoa Sperm motility Asthenozoospermia Infertility |
| title | Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
| title_full | Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
| title_fullStr | Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
| title_full_unstemmed | Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
| title_short | Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
| title_sort | proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
| topic | Proteome Spermatozoa Sperm motility Asthenozoospermia Infertility |
| url | http://link.springer.com/article/10.1186/s12958-018-0334-1 |
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