Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin
The article contains raw and analyzed data related to the research article “Neuronal ceroid lipofuscinosis genes, CLN2, CLN3, CLN5 are spatially and temporally co-expressed in a developing mouse brain” (Fabritius et al., 2014) [1]. The processed data gives an understanding of the development of the...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235234091630395X |
| _version_ | 1818989351599603712 |
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| author | Helena M. Minye Anna-Liisa Fabritius Jouni Vesa Leena Peltonen |
| author_facet | Helena M. Minye Anna-Liisa Fabritius Jouni Vesa Leena Peltonen |
| author_sort | Helena M. Minye |
| collection | DOAJ |
| description | The article contains raw and analyzed data related to the research article “Neuronal ceroid lipofuscinosis genes, CLN2, CLN3, CLN5 are spatially and temporally co-expressed in a developing mouse brain” (Fabritius et al., 2014) [1]. The processed data gives an understanding of the development of the cell types that are mostly affected by defective function of CLN proteins, timing of expression of CLN1, CLN2, CLN3 and CLN5 genes in a murine model. The data shows relationship between the expression pattern of these genes during neural development. Immunohistochemistry was used to identify known interneuronal markers for neurotransmission and cell proliferation: parvalbumin, somatostatin subpopulations of interneurons. Non-radioactive in-situ hybridization detected CLN5 mRNA in the hippocampus. Throughout the development strong expression of CLN genes were identified in the germinal epithelium and in ventricle regions, cortex, hippocampus, and cerebellum. This provides supportive evidence that CLN1, CLN2, CLN3 and CLN5 genes may be involved in synaptic pruning. Keywords: Neurogenetics, CLN genes, CLN1/CLN2/CLN3/CLN5, Embryonic neurogenesis, Neurotransmission, molecular genetics, Neuronal ceroid lipofuscinoses, Neuronal differentiation, neuroplasticity, and synaptic pruning |
| first_indexed | 2024-12-20T19:37:06Z |
| format | Article |
| id | doaj.art-4fe2f5cad63f4677a8ce43401c9826db |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-20T19:37:06Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-4fe2f5cad63f4677a8ce43401c9826db2022-12-21T19:28:36ZengElsevierData in Brief2352-34092016-09-018741749Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and SomatostatinHelena M. Minye0Anna-Liisa Fabritius1Jouni Vesa2Leena Peltonen3Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Corresponding author.Department of Applied Biology, University of Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USADepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USADepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Molecular Medicine, Biomedicum, National Public Health Institute, PO Box 104, FIN 00300 Helsinki, FinlandThe article contains raw and analyzed data related to the research article “Neuronal ceroid lipofuscinosis genes, CLN2, CLN3, CLN5 are spatially and temporally co-expressed in a developing mouse brain” (Fabritius et al., 2014) [1]. The processed data gives an understanding of the development of the cell types that are mostly affected by defective function of CLN proteins, timing of expression of CLN1, CLN2, CLN3 and CLN5 genes in a murine model. The data shows relationship between the expression pattern of these genes during neural development. Immunohistochemistry was used to identify known interneuronal markers for neurotransmission and cell proliferation: parvalbumin, somatostatin subpopulations of interneurons. Non-radioactive in-situ hybridization detected CLN5 mRNA in the hippocampus. Throughout the development strong expression of CLN genes were identified in the germinal epithelium and in ventricle regions, cortex, hippocampus, and cerebellum. This provides supportive evidence that CLN1, CLN2, CLN3 and CLN5 genes may be involved in synaptic pruning. Keywords: Neurogenetics, CLN genes, CLN1/CLN2/CLN3/CLN5, Embryonic neurogenesis, Neurotransmission, molecular genetics, Neuronal ceroid lipofuscinoses, Neuronal differentiation, neuroplasticity, and synaptic pruninghttp://www.sciencedirect.com/science/article/pii/S235234091630395X |
| spellingShingle | Helena M. Minye Anna-Liisa Fabritius Jouni Vesa Leena Peltonen Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin Data in Brief |
| title | Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin |
| title_full | Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin |
| title_fullStr | Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin |
| title_full_unstemmed | Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin |
| title_short | Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin |
| title_sort | data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes cln1 cln2 cln3 cln5 and their association to interneuron and neurotransmission markers parvalbumin and somatostatin |
| url | http://www.sciencedirect.com/science/article/pii/S235234091630395X |
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