Case Report: Phenotypic Switch in High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements: A Potential Mechanism of Therapeutic Resistance in Lymphoma?

Case Report: Phenotypic Switch in High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements: A Potential Mechanism of Therapeutic Resistance in Lymphoma?

Lineage switch between myeloid and lymphoid in acute leukemia is well established as a mechanism for leukemic cells to escape chemotherapy. Cross-lineage transformation is also recognized in some solid tumors on targeted therapy, such as adenocarcinomas of the lung and prostate that transforms to ne...

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Bibliographic Details
Main Authors: Hui Liu, Qi Shen, Chung-Che Chang, Shimin Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Oncology
Subjects:
High-grade B-cell lymphoma
MYC
BCL2
BCL6
plasmablastic lymphoma
lineage switch
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.795330/full

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