Complex I and MDM2: hit me baby one more time
MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Comple...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1607457 |
| _version_ | 1797677143255154688 |
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| author | Jerry Edward Chipuk |
| author_facet | Jerry Edward Chipuk |
| author_sort | Jerry Edward Chipuk |
| collection | DOAJ |
| description | MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2⋅NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis. |
| first_indexed | 2024-03-11T22:40:39Z |
| format | Article |
| id | doaj.art-4fe39395de7347a1a6ac30da2737e2e3 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:39Z |
| publishDate | 2019-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-4fe39395de7347a1a6ac30da2737e2e32023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-07-016410.1080/23723556.2019.16074571607457Complex I and MDM2: hit me baby one more timeJerry Edward Chipuk0Icahn School of Medicine at Mount SinaiMDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2⋅NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis.http://dx.doi.org/10.1080/23723556.2019.1607457apoptosiscomplex imdm2mitochondriandufs1 |
| spellingShingle | Jerry Edward Chipuk Complex I and MDM2: hit me baby one more time Molecular & Cellular Oncology apoptosis complex i mdm2 mitochondria ndufs1 |
| title | Complex I and MDM2: hit me baby one more time |
| title_full | Complex I and MDM2: hit me baby one more time |
| title_fullStr | Complex I and MDM2: hit me baby one more time |
| title_full_unstemmed | Complex I and MDM2: hit me baby one more time |
| title_short | Complex I and MDM2: hit me baby one more time |
| title_sort | complex i and mdm2 hit me baby one more time |
| topic | apoptosis complex i mdm2 mitochondria ndufs1 |
| url | http://dx.doi.org/10.1080/23723556.2019.1607457 |
| work_keys_str_mv | AT jerryedwardchipuk complexiandmdm2hitmebabyonemoretime |