Ocular Wnt/β-Catenin Pathway Inhibitor XAV939-Loaded Liposomes for Treating Alkali-Burned Corneal Wound and Neovascularization

Ocular Wnt/β-Catenin Pathway Inhibitor XAV939-Loaded Liposomes for Treating Alkali-Burned Corneal Wound and Neovascularization

Corneal wound involves a series of complex and coordinated physiological processes, leading to persistent epithelial defects and opacification. An obstacle in the treatment of ocular diseases is poor drug delivery and maintenance. In this study, we constructed a Wnt/β-catenin pathway inhibitor, XAV9...

Full description

Bibliographic Details
Main Authors:	Yueyang Zhong, Kai Wang, Yin Zhang, Qichuan Yin, Su Li, Jiaming Wang, Xiaobo Zhang, Haijie Han, Ke Yao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-10-01
Series:	Frontiers in Bioengineering and Biotechnology
Subjects:	liposomes Wnt/β-catenin pathway XAV939 corneal wound corneal neovascularization
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2021.753879/full

Similar Items

Ferrostatin‐1‐loaded liposome for treatment of corneal alkali burn via targeting ferroptosis
by: Kai Wang, et al.
Published: (2022-05-01)

Modelling of a targeted nanotherapeutic ‘stroma’ to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt–β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson’s disease
by: Jing-Wei Zhao, et al.
Published: (2014-10-01)

Docetaxel Resistance in Castration-Resistant Prostate Cancer: Transcriptomic Determinants and the Effect of Inhibiting Wnt/β-Catenin Signaling by XAV939
by: Elena Pudova, et al.
Published: (2022-10-01)

Targeting Wnt/β-catenin signaling using XAV939 nanoparticles in tumor microenvironment-conditioned macrophages promote immunogenicity
by: Chetan Pundkar, et al.
Published: (2023-06-01)

Wnt inhibitor XAV-939 promote the adipogenic differentiation of dental pulp stem cells
by: WEN Jun, et al.
Published: (2016-08-01)

Targeted dexamethasone nano-prodrug for corneal neovascularization management
by: Qichuan Yin, et al.
Published: (2024-02-01)

Inhibition of Wnt signalling pathway by XAV939 enhances radiosensitivity in human cervical cancer HeLa cells
by: Jinhua Zhang, et al.
Published: (2020-01-01)

Low Dose of Paclitaxel Combined with XAV939 Attenuates Metastasis, Angiogenesis and Growth in Breast Cancer by Suppressing Wnt Signaling
by: Dattatrya Shetti, et al.
Published: (2019-08-01)

Qici Sanling decoction suppresses bladder cancer growth by inhibiting the Wnt/Β-catenin pathway
by: Hua Gong, et al.
Published: (2019-01-01)

Celastrol nanomicelles attenuate cytokine secretion in macrophages and inhibit macrophage-induced corneal neovascularization in rats
by: Li Z, et al.
Published: (2016-11-01)

Therapeutic approaches for corneal neovascularization
by: Sepehr Feizi, et al.
Published: (2017-12-01)

The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor
by: Chen L, et al.
Published: (2018-09-01)

Use of Bevacizumab in the Treatment of Corneal Neovascularization
by: Tuba Çelik, et al.
Published: (2015-01-01)

Antibacterial and Zebrafish-based Screening for Wnt Signal Inhibitory Activities of Syzygium polycephaloides (C.B. Robb. Merr.) Bark Extracts
by: Rolly Garnace Fuentes, et al.
Published: (2021-05-01)

Comparison of the Therapeutic Efficacies of Topical Rivoceranib and Topical Bevacizumab in a Murine Model of Corneal Neovascularization
by: Hyeon Jeong Yoon, et al.
Published: (2019-11-01)

An Update on Novel Ocular Nanosystems with Possible Benefits in the Treatment of Corneal Neovascularization
by: Zhang C, et al.
Published: (2022-10-01)

A cell-permeable peptide inhibitor of p55PIK signaling alleviates suture-induced corneal neovascularization and inflammation
by: Jingyi Huang, et al.
Published: (2023-04-01)

Imaging methods of corneal neovascularization
by: Duo Xu, et al.
Published: (2019-08-01)

Suppression of corneal neovascularization by curcumin via inhibition of Wnt/β-catenin pathway activation
by: Yong-Kang Zhang, et al.
Published: (2017-12-01)

Peroxisome Proliferator-Activated Receptor Beta/Delta Agonist Suppresses Inflammation and Promotes Neovascularization
by: Yutaro Tobita, et al.
Published: (2020-07-01)

Epidemiology of Corneal Neovascularization and Its Impact on Visual Acuity and Sensitivity: A 14-Year Retrospective Study
by: Romina Mayra Lasagni Vitar, et al.
Published: (2021-10-01)

Preparation and Determination of In Vivo and In Vitro Performance of Doxycycline Imprinted Contact Lenses for Corneal Neovascularization Treatment
by: Sibel Erkal Ilhan, et al.
Published: (2018-10-01)

Preliminary study of rabbit model with corneal neovascularization after thermal burn under the constant temperature
by: Yong Jia, et al.
Published: (2014-07-01)

Inhibitory effect of anti-Scg3 on corneal neovascularization: a preliminary study
by: He Jin, et al.
Published: (2022-11-01)

Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization
by: Luca Pagano, et al.
Published: (2023-01-01)

Clickable corneal neovascularization therapy with ROS-responsive polydopamine silica nanoparticles loaded with fenofibrate
by: Kai Fan, et al.
Published: (2023-11-01)

Inhibitory effect of polysulfated heparin endostatin onalkali burn induced corneal neovascularization in rabbits
by: Zhao-Na Li, et al.
Published: (2015-04-01)

Comparison of different doses of subconjunctival sunitinib with bevacizumab in the treatment of corneal neovascularization in experimental rats
by: Mohammad Nasser Hashemian, et al.
Published: (2017-01-01)

Impaired Autophagy Causes Severe Corneal Neovascularization
by: Kun Yi, et al.
Published: (2022-12-01)

Inhibitory Effect of a Tankyrase Inhibitor on Mechanical Stress-Induced Protease Expression in Human Articular Chondrocytes
by: Yoshifumi Hotta, et al.
Published: (2024-01-01)

The effect of subconjunctival bevacizumab on corneal neovascularization, inflammation and re-epithelization in a rabbit model
by: Glauco Reggiani Mello, et al.
Published: (2011-01-01)

Application progress of transgenic mouse models of corneal neovascularization
by: Jian-Wen Fang*, et al.
Published: (2019-11-01)

Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization
by: Rui Zhang, et al.
Published: (2022-12-01)

Development of a naringenin microemulsion as a prospective ophthalmic delivery system for the treatment of corneal neovascularization: in vitro and in vivo evaluation
by: Yu Ma, et al.
Published: (2022-12-01)

Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/β-Catenin Signaling Pathway
by: Da Liu, et al.
Published: (2020-06-01)

Inhibition of Glycyrrhizin on acute alkali burn induced corneal neovascularization in mice
by: Pei-Hong Wang, et al.
Published: (2020-12-01)

Corrigendum: Ubiquitin C-Terminal hydrolase L5 (UCHL5) accelerates the growth of endometrial cancer via activating the Wnt/β-catenin signaling pathway
by: Da Liu, et al.
Published: (2022-08-01)

Multimodal Photoacoustic Imaging‐Guided Regression of Corneal Neovascularization: A Non‐Invasive and Safe Strategy
by: Chengchao Chu, et al.
Published: (2020-07-01)

Triamcinolone Acetonide as an Adjunct to Bevacizumab for Prevention of Corneal Neovascularization in a Rat Model
by: Hadi Z Mehrjardi, et al.
Published: (2014-01-01)

Prevent effect of Bevacizumab and Triamcinolone acetonide on corneal neovascularization induced by penetrating keratoplasty
by: Lan Li, et al.
Published: (2014-11-01)