Comparison of pulmonary mechanics during isoflurane, sevoflurane, and desflurane anesthesia
Background: Practicing anesthesia clinicians are aware that tracheal intubation increases resistance and alters pulmonary mechanics; thus, comparison of bronchodilating effects of volatile agents is desirable. This study was aimed to compare the respiratory mechanics during isoflurane, sevoflurane,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | The Indian Anaesthetists' Forum |
| Subjects: | |
| Online Access: | http://www.theiaforum.org/article.asp?issn=2589-7934;year=2018;volume=19;issue=2;spage=50;epage=55;aulast=Kale |
| _version_ | 1819141883147845632 |
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| author | Natasha Sainath Kale Vaijayanti Nitin Gadre |
| author_facet | Natasha Sainath Kale Vaijayanti Nitin Gadre |
| author_sort | Natasha Sainath Kale |
| collection | DOAJ |
| description | Background: Practicing anesthesia clinicians are aware that tracheal intubation increases resistance and alters pulmonary mechanics; thus, comparison of bronchodilating effects of volatile agents is desirable. This study was aimed to compare the respiratory mechanics during isoflurane, sevoflurane, and desflurane anesthesia at 1 minimum alveolar concentration (MAC) and 2 MAC.
Materials and Methods: Seventy patients undergoing moderate duration surgery were sequentially allocated into one of the three groups: Group I (Isoflurane; n = 23), Group S (Sevoflurane; n = 24), and Group D (Desflurane; n = 23). Peak inspiratory pressure (PIP), dynamic lung compliance (Cdyn), and airway resistance (Raw) values at three different time points were noted: 3 breaths after the start of mechanical ventilation (T1), 5 min after 1 MAC (T2), and 2 min after 2 MAC (T3).
Results: PIP increased significantly in the desflurane group by 6% at 1 MAC and 8.06% at 2 MAC from the baseline. Statistically significant increase in Cdyn by 1.59% at 1 MAC and 9.9% at 2 MAC was found in sevoflurane group. Raw decreased significantly by 24.28% at 1 MAC and by 45.65% at 2 MAC from the baseline in sevoflurane group.
Conclusions: We conclude that increasing concentrations from 1 MAC to 2 MAC show more consistent bronchodilating effect of Sevoflurane compared to isoflurane and desflurane. Sevoflurane increased Cdyn and reduced Raw from 1 MAC to 2 MAC. |
| first_indexed | 2024-12-22T12:01:31Z |
| format | Article |
| id | doaj.art-4fe5a45243124a3da240d763e636cc47 |
| institution | Directory Open Access Journal |
| issn | 2589-7934 0973-0311 |
| language | English |
| last_indexed | 2024-12-22T12:01:31Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Indian Anaesthetists' Forum |
| spelling | doaj.art-4fe5a45243124a3da240d763e636cc472022-12-21T18:26:35ZengWolters Kluwer Medknow PublicationsThe Indian Anaesthetists' Forum2589-79340973-03112018-01-01192505510.4103/TheIAForum.TheIAForum_25_18Comparison of pulmonary mechanics during isoflurane, sevoflurane, and desflurane anesthesiaNatasha Sainath KaleVaijayanti Nitin GadreBackground: Practicing anesthesia clinicians are aware that tracheal intubation increases resistance and alters pulmonary mechanics; thus, comparison of bronchodilating effects of volatile agents is desirable. This study was aimed to compare the respiratory mechanics during isoflurane, sevoflurane, and desflurane anesthesia at 1 minimum alveolar concentration (MAC) and 2 MAC. Materials and Methods: Seventy patients undergoing moderate duration surgery were sequentially allocated into one of the three groups: Group I (Isoflurane; n = 23), Group S (Sevoflurane; n = 24), and Group D (Desflurane; n = 23). Peak inspiratory pressure (PIP), dynamic lung compliance (Cdyn), and airway resistance (Raw) values at three different time points were noted: 3 breaths after the start of mechanical ventilation (T1), 5 min after 1 MAC (T2), and 2 min after 2 MAC (T3). Results: PIP increased significantly in the desflurane group by 6% at 1 MAC and 8.06% at 2 MAC from the baseline. Statistically significant increase in Cdyn by 1.59% at 1 MAC and 9.9% at 2 MAC was found in sevoflurane group. Raw decreased significantly by 24.28% at 1 MAC and by 45.65% at 2 MAC from the baseline in sevoflurane group. Conclusions: We conclude that increasing concentrations from 1 MAC to 2 MAC show more consistent bronchodilating effect of Sevoflurane compared to isoflurane and desflurane. Sevoflurane increased Cdyn and reduced Raw from 1 MAC to 2 MAC.http://www.theiaforum.org/article.asp?issn=2589-7934;year=2018;volume=19;issue=2;spage=50;epage=55;aulast=KaleDesfluraneisofluranepulmonary mechanicssevoflurane |
| spellingShingle | Natasha Sainath Kale Vaijayanti Nitin Gadre Comparison of pulmonary mechanics during isoflurane, sevoflurane, and desflurane anesthesia The Indian Anaesthetists' Forum Desflurane isoflurane pulmonary mechanics sevoflurane |
| title | Comparison of pulmonary mechanics during isoflurane, sevoflurane, and desflurane anesthesia |
| title_full | Comparison of pulmonary mechanics during isoflurane, sevoflurane, and desflurane anesthesia |
| title_fullStr | Comparison of pulmonary mechanics during isoflurane, sevoflurane, and desflurane anesthesia |
| title_full_unstemmed | Comparison of pulmonary mechanics during isoflurane, sevoflurane, and desflurane anesthesia |
| title_short | Comparison of pulmonary mechanics during isoflurane, sevoflurane, and desflurane anesthesia |
| title_sort | comparison of pulmonary mechanics during isoflurane sevoflurane and desflurane anesthesia |
| topic | Desflurane isoflurane pulmonary mechanics sevoflurane |
| url | http://www.theiaforum.org/article.asp?issn=2589-7934;year=2018;volume=19;issue=2;spage=50;epage=55;aulast=Kale |
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