The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability

The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability

Summary: The target of Rapamycin complex1 (TORC1) senses and integrates several environmental signals, including amino acid (AA) availability, to regulate cell growth. Folliculin (FLCN) is a tumor suppressor (TS) protein in renal cell carcinoma, which paradoxically activates TORC1 in response to AA...

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Bibliographic Details
Main Authors: Isabel A. Calvo, Shalini Sharma, Joao A. Paulo, Alexander O.D. Gulka, Andras Boeszoermenyi, Jingyu Zhang, Jose M. Lombana, Christina M. Palmieri, Laura A. Laviolette, Haribabu Arthanari, Othon Iliopoulos, Steven P. Gygi, Mo Motamedi
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Cellular physiology
Cell biology
Functional aspects of cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221013079

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http://www.sciencedirect.com/science/article/pii/S2589004221013079

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