Secondary Metabolites and Their Cytotoxic Activity of <i>Artemisia nitrosa</i> Weber. and <i>Artemisia marschalliana</i> Spreng.
As a promising source of biologically active substances, the <i>Artemisia</i> species from Kazakhstan have not been investigated efficiently. Considering the rich history, medicinal values, and availability of the <i>Artemisia</i> plants, systematic investigations of two <...
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/22/8074 |
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| author | Aizhan Kazymbetova Magzhan Amangeldi Aliya Nurlybekova Ulpan Amzeyeva Kunbike Baktybala Chun-Ping Tang Chang-Qiang Ke Sheng Yao Yang Ye Janar Jenis |
| author_facet | Aizhan Kazymbetova Magzhan Amangeldi Aliya Nurlybekova Ulpan Amzeyeva Kunbike Baktybala Chun-Ping Tang Chang-Qiang Ke Sheng Yao Yang Ye Janar Jenis |
| author_sort | Aizhan Kazymbetova |
| collection | DOAJ |
| description | As a promising source of biologically active substances, the <i>Artemisia</i> species from Kazakhstan have not been investigated efficiently. Considering the rich history, medicinal values, and availability of the <i>Artemisia</i> plants, systematic investigations of two <i>Artemisia</i> species growing in the East Kazakhstan region were conducted. In this study, one new germacrane-type sesquiterpene lactone (<b>11</b>), together with 10 known sesquiterpenes and its dimer, were characterized from <i>A. nitrosa</i> Weber. Additionally, one new chromene derivative (<b>1</b>’) with another 12 known compounds, including coumarins, sesquiterpene diketones, phenyl propanoids, polyacetylenics, dihydroxycinnamic acid derivatives, fatty acids, naphthalene derivatives, flavones, and caffeic acid derivatives were isolated from <i>A. marschalliana</i> Spreng. All compounds were isolated and identified for the first time from these two <i>Artemisia</i> species. The structures of new compounds (<b>11</b>, <b>1</b>’) were established by using UV, TOFMS, LC–MS, 1D and 2D NMR spectroscopic analyses. The cytotoxicity of all isolated compounds was evaluated. As a result, all compounds did not show significant inhibition against HL-60 and A-549 cell lines. The sesquiterpenoids isolated from <i>A. nitrosa</i> were tested for their inhibitory activity against the LPS-induced NO release from the RAW624.7 cells, and neither of them exhibited significant activity. |
| first_indexed | 2024-03-09T18:06:50Z |
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| id | doaj.art-4fe6bdbb85a04f738dd1f2885aa9a1dd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:06:50Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4fe6bdbb85a04f738dd1f2885aa9a1dd2023-11-24T09:26:03ZengMDPI AGMolecules1420-30492022-11-012722807410.3390/molecules27228074Secondary Metabolites and Their Cytotoxic Activity of <i>Artemisia nitrosa</i> Weber. and <i>Artemisia marschalliana</i> Spreng.Aizhan Kazymbetova0Magzhan Amangeldi1Aliya Nurlybekova2Ulpan Amzeyeva3Kunbike Baktybala4Chun-Ping Tang5Chang-Qiang Ke6Sheng Yao7Yang Ye8Janar Jenis9The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabi ave. 71, Almaty 050040, KazakhstanThe Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabi ave. 71, Almaty 050040, KazakhstanThe Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabi ave. 71, Almaty 050040, KazakhstanThe Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabi ave. 71, Almaty 050040, KazakhstanThe Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabi ave. 71, Almaty 050040, KazakhstanState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaUniversity of Chinese Academy of Sciences, Beijing 100049, ChinaThe Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabi ave. 71, Almaty 050040, KazakhstanAs a promising source of biologically active substances, the <i>Artemisia</i> species from Kazakhstan have not been investigated efficiently. Considering the rich history, medicinal values, and availability of the <i>Artemisia</i> plants, systematic investigations of two <i>Artemisia</i> species growing in the East Kazakhstan region were conducted. In this study, one new germacrane-type sesquiterpene lactone (<b>11</b>), together with 10 known sesquiterpenes and its dimer, were characterized from <i>A. nitrosa</i> Weber. Additionally, one new chromene derivative (<b>1</b>’) with another 12 known compounds, including coumarins, sesquiterpene diketones, phenyl propanoids, polyacetylenics, dihydroxycinnamic acid derivatives, fatty acids, naphthalene derivatives, flavones, and caffeic acid derivatives were isolated from <i>A. marschalliana</i> Spreng. All compounds were isolated and identified for the first time from these two <i>Artemisia</i> species. The structures of new compounds (<b>11</b>, <b>1</b>’) were established by using UV, TOFMS, LC–MS, 1D and 2D NMR spectroscopic analyses. The cytotoxicity of all isolated compounds was evaluated. As a result, all compounds did not show significant inhibition against HL-60 and A-549 cell lines. The sesquiterpenoids isolated from <i>A. nitrosa</i> were tested for their inhibitory activity against the LPS-induced NO release from the RAW624.7 cells, and neither of them exhibited significant activity.https://www.mdpi.com/1420-3049/27/22/8074<i>Artemisia nitrosa</i><i>Artemisia marschalliana</i>sesquiterpene lactonecoumarinflavonoidphenolic compound |
| spellingShingle | Aizhan Kazymbetova Magzhan Amangeldi Aliya Nurlybekova Ulpan Amzeyeva Kunbike Baktybala Chun-Ping Tang Chang-Qiang Ke Sheng Yao Yang Ye Janar Jenis Secondary Metabolites and Their Cytotoxic Activity of <i>Artemisia nitrosa</i> Weber. and <i>Artemisia marschalliana</i> Spreng. Molecules <i>Artemisia nitrosa</i> <i>Artemisia marschalliana</i> sesquiterpene lactone coumarin flavonoid phenolic compound |
| title | Secondary Metabolites and Their Cytotoxic Activity of <i>Artemisia nitrosa</i> Weber. and <i>Artemisia marschalliana</i> Spreng. |
| title_full | Secondary Metabolites and Their Cytotoxic Activity of <i>Artemisia nitrosa</i> Weber. and <i>Artemisia marschalliana</i> Spreng. |
| title_fullStr | Secondary Metabolites and Their Cytotoxic Activity of <i>Artemisia nitrosa</i> Weber. and <i>Artemisia marschalliana</i> Spreng. |
| title_full_unstemmed | Secondary Metabolites and Their Cytotoxic Activity of <i>Artemisia nitrosa</i> Weber. and <i>Artemisia marschalliana</i> Spreng. |
| title_short | Secondary Metabolites and Their Cytotoxic Activity of <i>Artemisia nitrosa</i> Weber. and <i>Artemisia marschalliana</i> Spreng. |
| title_sort | secondary metabolites and their cytotoxic activity of i artemisia nitrosa i weber and i artemisia marschalliana i spreng |
| topic | <i>Artemisia nitrosa</i> <i>Artemisia marschalliana</i> sesquiterpene lactone coumarin flavonoid phenolic compound |
| url | https://www.mdpi.com/1420-3049/27/22/8074 |
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